Roman Zak

John F Engelhardt4
Ziying Yan4
4John F Engelhardt
4Ziying Yan
Learn More
We have previously demonstrated that hybrid adeno-associated viral (AAV) vectors bearing nonhomologous inverted terminal repeats (ITRs) enhance directional intermolecular recombination and the efficiency of dual-AAV vector trans-splicing in cultured cells. Using hybrid-ITR vectors carrying two exons of a lacZ minigene, we demonstrate that this dual-vector(More)
Recombinant adeno-associated virus (rAAV) vectors possess the unique ability to introduce genetic alterations at sites of homology in genomic DNA through a mechanism thought to predominantly involve homologous recombination. We have investigated the efficiency of this approach using a mutant enhanced green fluorescent protein (eGFP) fluorescence recovery(More)
The choice of adeno-associated virus serotypes for clinical applications is influenced by the animal model and model system used to evaluate various serotypes. In the present study, we sought to compare the biologic properties of rAAV2/1, rAAV2/2, and rAAV2/5 transduction in polarized human airway epithelia using viruses purified by a newly developed common(More)
The relatively small package capacity (less than 5 kb) of adeno-associated virus (AAV) vectors has been effectively doubled with the development of dual-vector heterodimerization approaches. However, the efficiency of such dual-vector systems is limited not only by the extent to which intermolecular recombination occurs between two independent vector(More)
Aim of this article is to clarify the potential use of EEG signal in modern information age. The basic principle of Brain Computer Interface (BCI) lies in the connection of brain waves with output device through some interface. BCI technology represents a communication interface between brain and computer. To sense electric signal from the brain, it is(More)
The basic idea of Brain-Computer Interface (BCI) is the connection of brain waves with an output device through some interface. Aim of this article is to clarify the potential utilization of complex EEG signal in BCI system. For this purpose, real application of BCI technology was designed and tested. This paper describes this real application in detail and(More)
  • 1