Roman Valls

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A new method for the determination of cyclophosphamide content of polyalkylcyanoacrylate nanoparticles was developed. The analyses were carried out by inductively coupled plasma atomic emission spectrometry (ICP-AES) by measuring the phosphorus content in the drug. The results obtained by this non-selective technique were compared with those given by high(More)
A model of a corneal apparatus for the study of drug permeation across the corneal tissues is evaluated. The instrument was designed to measure drug transport in living rabbit corneas, which are placed hermetically into a chamber, separating it into two compartments (epithelial and endothelial). The device also allows the measurement and recording of the(More)
This work is focused on the ex vivo study of corneal permeation of two anti-inflammatory drugs: diclofenac, and flurbiprofen (as a model of hydrophilic and lipophilic drug, respectively) loaded to cyclodextrins or polymeric nanoparticles in order to determine differences in their corneal permeation against free drug or commercial eye drops. These studies(More)
Genome-wide association studies (GWAS) has been in the heart of medical research for the last 5 years. These studies seek for common variants in the genome that are linked to risk for common complex diseases (CCDs). Although GWAS has defined a number of interesting genetic loci for a range of CCDs, the current GWAS analysis has limitation such as(More)
The existence of a low-bone turnover, non-aluminium related, has been more prevalent in recent years. Factors involved include the increasing number of older and diabetic patients initiating dialysis. Also higher intake of calcium salts and the widespread use of vitamin D derivates may play a role. Demonstration of low PTH secretion allows the recognition(More)
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