Roman Kurynin

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The VHL gene is often inactivated in sporadic clear cell renal cancer (CCRC) due to somatic mutations, and its germline mutations cause hereditary CCRC: von Hippel-Lindau syndrome. Localization of mutations in VHL, identification of new mutations, and their influence on CCRC progression and sensitivity to targeted therapy are topical problems in modern(More)
In the paper we describe the NMF-based approach applied to the problem of determining an employee's access needs. The conducted research showed that the proposed NMF-based methods provide a useful analytical framework for processing and modeling employee's access needs data, and the obtained results demonstrate acceptable performance and provide descriptive(More)
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