Roman Kurynin

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The VHL gene is often inactivated in sporadic clear cell renal cancer (CCRC) due to somatic mutations, and its germline mutations cause hereditary CCRC: von Hippel-Lindau syndrome. Localization of mutations in VHL, identification of new mutations, and their influence on CCRC progression and sensitivity to targeted therapy are topical problems in modern(More)
We developed a new method for evaluation of the purity of cell population in primary cultures of hepatocellular carcinoma. Expression of potential surface molecular markers on primary cultures of renal tumors was assayed by the method of flow cytofluorometry. CD24 and CD70 were identified as differential markers, which allowed us to distinguish cancer cells(More)
In the paper we describe the NMF-based approach applied to the problem of determining an employee's access needs. The conducted research showed that the proposed NMF-based methods provide a useful analytical framework for processing and modeling employee's access needs data, and the obtained results demonstrate acceptable performance and provide descriptive(More)
The present paper discusses different techniques of measuring Carrier-to-Noise density ratio (C/N<inf>0</inf>) in navigation and information-communication systems. C/N<inf>0</inf> means the ratio of the received signal power to the noise spectral density N<inf>0</inf> at receiver's input (at the output of an antenna with a low-noise amplifier (LNA)).(More)
Clear cell renal carcinoma (CCRC) accounts for 75% of all renal cancer cases. The majority of CCRCs displays inactivation of the VHL suppressor gene as a result of mutations, allelic deletions, and/or methylation. Data on the effect of VHL inactivation on the prognosis in CCRC are discrepant. Comprehensive molecular genetic analysis of VHL was performed for(More)
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