Roman Kessler

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In Drosophila Pygopus (Pygo) and Legless (Lgs)/BCL9 are integral components of the nuclear Wnt/Wg signaling machine. Despite intense research, ideas that account for their mode of action remain speculative. One proposition, based on a recently discovered function of PHD fingers, is that Pygo, through its PHD, may decipher the histone code. We found that(More)
Lacking vision, blind people have to exploit other senses for navigation. Using the tactile rather than the auditory sense avoids masking important environmental information. Directional information is particularly important and traditionally conveyed through an array of tactors, each coding one direction. Here, we present a different approach to represent(More)
dDsk2 is a conserved extraproteasomal ubiquitin receptor that targets ubiquitylated proteins for degradation. Here we report that dDsk2 plays a nonproteolytic function in transcription regulation. dDsk2 interacts with the dHP1c complex, localizes at promoters of developmental genes and is required for transcription. Through the ubiquitin-binding domain,(More)
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