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High-frequency cortical activity, particularly in the 250-600 Hz (fast ripple) band, has been implicated in playing a crucial role in epileptogenesis and seizure generation. Fast ripples are highly specific for the seizure initiation zone. However, evidence for the association of fast ripples with epileptic foci depends on animal models and human cases with(More)
An assessment of vocal impairment is presented for separating healthy people from persons with early untreated Parkinson's disease (PD). This study's main purpose was to (a) determine whether voice and speech disorder are present from early stages of PD before starting dopaminergic pharmacotherapy, (b) ascertain the specific characteristics of the(More)
Sturge-Weber syndrome is a neurocutaneous disorder classically characterized by the presence of facial port-wine stain and ipsilateral leptomeningeal angiomatosis. It is often associated with refractory epilepsy which requires surgical treatment. We present a case of a patient who initially presented with partial seizures of temporo-occipital origin,(More)
The purpose of this study was to analyze vowel articulation across various speaking tasks in a group of 20 early Parkinson's disease (PD) individuals prior to pharmacotherapy. Vowels were extracted from sustained phonation, sentence repetition, reading passage, and monologue. Acoustic analysis was based upon measures of the first (F1) and second (F2)(More)
The contribution addresses a sliding window modification of the Bayesian autoregressive change-point detector (BACD) enabling the sequential localization of signal changes (change-point detection). The modification consists in using the simplified data-dependent Bayesian evidence normalizing the classical BACD formula and in the recursive evaluation of(More)
Despite the initial reports showing beneficial effects of dopaminergic treatment on speech in Parkinson's disease (PD), more recent studies based upon valid measurements have not approved any improvement of speech performance under pharmacotherapy. The aim of this study was to analyze the effect of treatment initiation on the progression of speech(More)
Diamond-Blackfan anemia (DBA; OMIM:105650) attracts much attention, because symptoms are associated with mutations in RPS19 1 and RPS24 2 in 25% and 2% of DBA patients, respectively, indicating a possible relationship between the ribosomal function, translation levels and erythropoiesis. Indeed, in our recent study we showed that translational efficiency(More)