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OBJECTIVE To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock," published in 2004. DESIGN Modified Delphi method with a consensus conference of 55 international experts, several subsequent meetings of subgroups and key(More)
Objective: To provide an update to the " Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock, " last published in 2008. Design: A consensus committee of 68 international experts representing 30 international organizations was convened. Nominal groups were assembled at key international meetings (for those committee members(More)
BACKGROUND Systems that are used by different organisations to grade the quality of evidence and the strength of recommendations vary. They have different strengths and weaknesses. The GRADE Working Group has developed an approach that addresses key shortcomings in these systems. The aim of this study was to pilot test and further develop the GRADE approach(More)
OBJECTIVE Circulatory shock is a life-threatening syndrome resulting in multiorgan failure and a high mortality rate. The aim of this consensus is to provide support to the bedside clinician regarding the diagnosis, management and monitoring of shock. METHODS The European Society of Intensive Care Medicine invited 12 experts to form a Task Force to update(More)
Objectif : Apporter une mise à jour au guide de la campagne « Surviving Sepsis » (Survivre au sepsis) pour la prise en charge du sepsis sévère et du choc septique, publié pour la dernière fois en 2008. Description : Un comité consensuel de 68 experts internationaux représentant 30 organisations internationales a été formé. Des groupes nominaux ont été(More)
Background: Pulmonary embolism (PE) is a leading cause of maternal mortality in the developed world. Along with appropriate prophy-laxis and therapy, prevention of death from PE in pregnancy requires a high index of clinical suspicion followed by a timely and accurate diagnostic approach. Methods: To provide guidance on this important health issue, a(More)
INTRODUCTION Although intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) are associated with substantial morbidity and mortality among critically ill adults, it remains unknown if prevention or treatment of these conditions improves patient outcomes. We sought to identify evidence-based risk factors for IAH and ACS in order to guide(More)
INTRODUCTION Randomized trials investigating neuromuscular blocking agents in adult acute respiratory distress syndrome (ARDS) have been inconclusive about effects on mortality, which is very high in this population. Uncertainty also exists about the associated risk of ICU-acquired weakness. METHODS We conducted a systematic review and meta-analysis. We(More)