Roman Bayandin

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Retroviral integrase (IN) catalyzes the integration of double-stranded viral DNA into the host cell genome. The reaction can be divided in two steps: 3'-end processing and DNA strand transfer. Here we studied the effect of short oligonucleotides (ODNs) on human immunodeficiency virus type 1 (HIV-1) IN. ODNs were either specific, with sequences representing(More)
Human immunodeficiency virus type 1 (HIV-1) integrase (IN) is an essential enzyme in the life cycle of the retrovirus, responsible for catalysing the insertion of the viral genome into the host cell chromosome. For this reason it provides an attractive target for antiviral drug design. We synthesized a series of novel thiazole (Tz)-containing oligopeptides(More)
In the study were included one group of acute hepatitis patients (1043 persons) of Barnaul's city hospital and four groups (500 persons in each group) of Novosibirsk's oblast inhabitants: medical staff, patients drug abuse clinic, AIDS center's patients, clinic patients applied for any disease. The frequency of HBsAg was: 3.6% in group of polyclinic(More)
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