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In this paper we present OpenMOLE, a scientific framework providing a virtualized runtime environment for distributed computing. Current distributed execution systems do not hide the hardware and software heterogeneity of computing and data resources whereas OpenMOLE provides generic services to develop distributed scientific algorithms independently from… (More)

Monte Carlo simulations are increasingly used in medical physics. In scintigraphic imaging these simulations are used to model imaging systems and to develop and assess tomographic reconstruction algorithms and correction methods for improved image quantization. In radiotherapy-brachytherapy the goal is to evaluate accurately the dosimetry in complex… (More)

Complex-systems describe multiple levels of collective structure and organization. In such systems, the emergence of global behaviour from local interactions is generally studied through large scale experiments on numerical models. This analysis generates important computation loads which require the use of multi-core servers, clusters or grid computing.… (More)

Bayesian networks are stochastic models, widely adopted to encode knowledge in several fields. One of the most interesting features of a Bayesian network is the possibility of learning its structure from a set of data, and subsequently use the resulting model to perform new predictions. Structure learning for such models is a NP-hard problem, for which the… (More)

- Vincent Breton, Ana Lucia da Costa, Paul de Vlieger, Young-Min Kim, Lydia Maigne, Romain Reuillon +5 others
- Infectious disorders drug targets
- 2009

The recent years have seen the emergence of diseases which have spread very quickly all around the world either through human travels like SARS or animal migration like avian flu. Among the biggest challenges raised by infectious emerging diseases, one is related to the constant mutation of the viruses which turns them into continuously moving targets for… (More)

Viability theory is a very attractive theoretical approach for the modeling of complex dynamical systems. However, its scope of application is limited due to the high computational power it necessitates. Evolutionary computation is a convenient way to address some issues related to this theory. In this paper, we present a multi-objective evolutionary… (More)

Multi-agent geographical models integrate very large numbers of spatial interactions. In order to validate those models large amount of computing is necessary for their simulation and calibration. Here a new data processing chain including an automated calibration procedure is experimented on a computational grid using evolutionary algorithms. This is… (More)

- Romain Reuillon
- 2008

In the framework of Decision Support Systems, mathematical viability theory can be used to classify the states and the trajectories of a dynamical system evolving in a set of desirable states. Since obtaining this viability theory output is a complex and computationally intensive task, we propose in this article to consider a compact representation of this… (More)