Romain Mathieu

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Prostate segmentation in 3-D transrectal ultrasound images is an important step in the definition of the intra-operative planning of high intensity focused ultrasound (HIFU) therapy. This paper presents two main approaches for the semi-automatic methods based on discrete dynamic contour and optimal surface detection. They operate in 3-D and require a(More)
OBJECTIVE This study focuses on laparoscopic nephrectomy for autosomal dominant polycystic kidney disease (ADPKD). MATERIAL AND METHODS We retrospectively reviewed 21 consecutive patients who had previously undergone laparoscopy between 2007 and 2010. Data were compared to that obtained from 19 consecutive patients who had open surgery between 2004 and(More)
PURPOSE Upper tract urothelial carcinoma (UTUC) is a rare and poorly investigated disease. Intense collaborative efforts have increased our knowledge and improved the management of the disease. The objective of this review was to discuss recent advances and unmet needs in UTUC. METHODS A non-systematic Medline/PubMed literature search was performed on(More)
OBJECTIVE To analyze late urinary toxicity after prostate cancer radiotherapy (RT): symptom description and identification of patient characteristics or treatment parameters allowing for the generation of nomograms. METHODS Nine hundred and sixty-five patients underwent RT in seventeen French centers for localized prostate cancer. Median total dose was 70(More)
OBJECTIVE Several retrospective studies with small cohorts reported neutrophil-to-lymphocyte ratio (NLR) as a prognostic marker in upper tract urothelial carcinoma (UTUC) following radical nephroureterectomy (RNU). We aimed at validating the predictive and prognostic role of NLR in a large multi-institutional cohort. METHODS Preoperative NLR was assessed(More)
Urothelial carcinoma of the bladder (UCB) and upper tract (UTUC) are now established as two distinct entities with differences in anatomical, biological and molecular characteristics. Indeed, specific clinical guidelines have been produced for each of them to guide clinicians (1-3). Despite their status of " disparate twins " , UCB and UTUC still share(More)
Vertebrates developed sophisticated solutions to select environmental visual information, being capable of moving attention without moving the eyes. A large body of behavioral and neuroimaging studies indicate a tight coupling between eye movements and spatial attention. The nature of this link, however, remains highly debated. Here, we demonstrate that(More)
Multi-parametric magnetic resonance imaging (mMRI) is the standard exam for prostate cancer diagnosis, staging and risk assessment in current clinical routine. Correlating mMRI in-vivo observations with biological findings from radical prostatectomy specimen would improve the optimal therapy selection. Thus, we proposed a method for reconstructing and(More)
Locally advanced (T3b, T4 and N1-N3) and metastatic urothelial bladder cancer (BCa) is a lethal disease with poor survival outcomes. Combination chemotherapy remains the treatment of choice in patients with metastatic disease and an important part of treatment in addition to radical cystectomy (RC) in patients with locally advanced tumour. Approximately(More)