Romain Guidoux

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This study aims to determine if isoprostanes accurately reflect in vivo lipid peroxidation or whether they are influenced by the lipid content of the diet. Isoprostanes were measured in urine of healthy subjects under different conditions of lipid intake and under conditions of oxidative stress (fasting). We found that isoprostanes were not influenced by(More)
The oxidation of the C-1 atom of glucose through the pentose shunt of adipose tissue, under maximal stimulation by insulin, was enhanced by rat serum. The material responsible for the increase of the efficacy of insulin by serum was ultrafiltrable and partly dialysable. At submaximal concentrations of insulin, the serum-induced enhancement of responses to(More)
This paper introduces a function dedicated to the estimation of total energy expenditure (TEE) of daily activities based on data from accelerometers integrated into smartphones. The use of mass-market sensors such as accelerometers offers a promising solution for the general public due to the growing smartphone market over the last decade. The TEE(More)
The proliferation of smartphones is creating new opportunities to monitor and interact with human subjects in free-living conditions since smartphones are familiar to large segments of the population and facilitate data collection, transmission and analysis. From accelerometry data collected by smartphones, the present work aims to estimate time spent in(More)
2-Oxoglutarate-supported rat liver mitochondria were loaded with moderate amounts of calcium and submitted to O2 deprivation and reoxygenation. In the presence of acetoacetate, anaerobic energy production maintained Ca2+ retention by mitochondria during the anoxia period unless the Pi concentration of the incubation solution was raised to 4-6 mM.(More)
Large doses of hydrochlorothiazide (50-200mg/kg/day p.o.) given for 5 to 6 weeks did not induce any increase in the fasting blood-sugar concentration, nor any decrease of glucose tolerance in normal rats and in rats “sensitized” toward diabetogenic agents by a subtotal pancreatectomy or by a sub-diabetogenic dose of alloxan. No increase in blood sugar was(More)
L'effet activateur de l'insuline, in vitro, sur la formation de glycogène musculaire, était inhibé par la présence d'urée dans le milieu d'incubation. Ce phénomène a été observé sur deux modèles expérimentaux: le diaphragme et le muscle grand dentelé du rat. Le mode par lequel l'urée s'oppose à l'action de l'insuline est discuté.
Insulin is degraded in plasma or serum from NMMAA-diabetic rats, at 37 degrees C in vitro, as shown by losses of both immunoreactivity and biological activity on fat pad tissue. The rate of insulin degradation was not notably influenced by plasma pH, in the range 7.2-8.3. Presumably due to destruction of insulin in the course of the 120 min bioassay(More)