Romain Colle

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An association between serotonin 2A receptor (5-HT2AR), encoded by HTR2A gene, and major depressive disorder (MDD) has been suggested. Here, we combined preclinical and ecological clinical approaches to explore the impact of impaired 5-HT2AR-mediated transmission on MDD or anxio-depressive-like phenotype in mice. Htr2a knock-out mice (Htr2a(-/-)) and(More)
This paper presents Oracle Database Replay, a novel approach to testing changes to the relational database management system component of an information system (software upgrades, hardware changes etc). Database Replay makes it possible to subject a test system to a real production system workload, which helps identify all potential problems before(More)
Oracle Database Replay provides a new way to test changes to a database system by reproducing the real user workload in a test environment. It helps to identify potential problems after software or hardware upgrades, patches, or changes to database parameters, schema or data. Any interesting workload period of a production database system can be captured(More)
BACKGROUND Despite known relationship between hippocampal volumes and major depressive episodes (MDE) and the increased suicidality in MDE, the links between hippocampal volumes and suicidality remain unclear in major depressive disorders (MDD). If the hippocampus could be a biomarker of suicide attempts in depression, it could be useful for prevention(More)
Oracle Database Replay has been recently introduced in Oracle 11g as a novel tool to test relational database systems [9]. It involves recording the workload running on the database server in a production system, and subsequently replaying it on the database server in a test system. A key feature of workload replay that enables realistic reproduction of a(More)
This paper presents the Oracle solution for database testing delivered in the Oracle 11g Database Real Application Testing option. The first feature, the SQL Performance Analyzer, performs unit testing of the SQL of a production workload. The second feature, Database Replay, makes it possible to subject a test system to a real production system workload.(More)
Metabolomic approaches are increasingly used to identify new disease biomarkers, yet normal values of many plasma metabolites remain poorly defined. The aim of this study was to define the "normal" metabolome in healthy volunteers. We included 800 French volunteers aged between 18 and 86, equally distributed according to sex, free of any medication and(More)
BACKGROUND Three studies assessed the association of early life adversity (ELA) and hippocampal volumes in depressed patients, of which one was negative and the two others did not control for several potential confounding variables. Since the association of ELA and hippocampal volumes differ in male and female healthy volunteers, we investigated the(More)
BACKGROUND Pioglitazone, a selective agonist of the nuclear transcription factor peroxisome proliferator-activated receptor-gamma (PPAR-γ), prescribed for the treatment of type 2 diabetes, could have antidepressant properties. However, its potential to induce remission of major depressive episodes, the optimal clinical target for an antidepressant drug, is(More)