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In Alzheimer's disease (AD) inflammatory processes occur in pathologically vulnerable brain regions. The objective of this study is to compare both the release and the presence of microvessel-associated cytokines in vessels isolated from the brains of AD patients to microvessels from control brains. Microvessels are isolated from the cortices of AD patients(More)
Inflammatory mechanisms are thought to contribute to lesion pathogenesis and neuronal cell death in Alzheimer's disease. Transforming growth factor-beta (TGF-beta) plays a central role in the response of the brain to injury, and is increased in the brain in Alzheimer's disease. In this study we determine whether expression of TGF-beta is abnormal in the(More)
Increasing evidence suggests that the regulation of neuronal cell death is complex. In this study we compared the neurotoxic effects of tumor necrosis factor-alpha (TNFalpha), nitric oxide, and thrombin on primary rat cortical cell cultures and the neuronal PC12 cell line. Release of lactate dehydrogenase (LDH) and the intracellular accumulation of(More)
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