Roly Foulkes

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BACKGROUND Inhibitors of tumor necrosis factor alpha (TNFalpha) have demonstrated significant efficacy in chronic inflammatory diseases, including Crohn's disease (CD). To further elucidate the mechanisms of action of these agents, we compared the anti-TNFalpha agents certolizumab pegol, infliximab, adalimumab, and etanercept in several in vitro systems. (More)
Monoclonal antibodies (mAbs) can be potent and specific therapeutics with long plasma half-lives and therefore long exposure times, which are now being clinically used to treat chronic disorders. Their recombinant design means some of their behaviours in the clinic can be determined at the design stage. However, their specific nature means a flexible(More)
Certolizumab pegol (CZP) is a PEGylated Fab' fragment of a humanized monoclonal immunoglobulin G (IgG)1 antibody that binds to human tumor necrosis factor alpha (TNFα) with high affinity. As for many monoclonal antibodies (mAbs), nonclinical safety assessment of CZP has been constrained because of its limited species cross-reactivity and recognition of only(More)
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