Rolf Kleinschmidt

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PURPOSE Outcomes in patients with brain metastases undergoing whole-brain radiotherapy (WBRT) are hardly encouraging, and an improvement in results is therefore needed. One possible approach is the addition of chemotherapeutics. However the data presented thus far are also disappointing. A promising substance in this setting could become topotecan, which is(More)
BACKGROUND Irinotecan is an established therapeutic option in colorectal cancer. An essential side effect of irinotecan treatment is the induction of severe WHO grade 3-4 delayed diarrhea in up to 25% of treated patients. The aim of the study is the prevention of delayed diarrhea with cholestyramine/levofloxacin. PATIENTS AND METHODS Fifty-one patients(More)
The interesting nexus of problems related to the behaviour of the T-cell effected immunity situation of patients treated by means of cryosurgery and operations, was commenced by examinations of 118 women in regard of the transformability of lymphocytes. By the help of swab-preparations and especially of the PHA-stimulated lymphocyte transformation test,(More)
The identification of psychosocial stress in cancer patients has remained a challenging task especially in an acute care environment. The aims of the present study were to apply a short expert rating scale for the assessment of distress during the acute treatment phase and to identify potential sociodemographic and disease-related predictors. Four hundred(More)
We report of a 34-year old man with second intracranial relapse of a suprasellar germinoma. Despite of extensive pretreatment with radiation and conventional chemotherapy relapse occurred and was treated with sequential high-dose chemotherapy followed by transfusion of autologous peripheral stem cells. The high-dose chemotherapy course was complicated by(More)
In the Gynecological Hospital of the Academy Erfut, the deliveries of the year 1973 were analysed prospectively in regard of the frequency of umbilical cord complications and their effects to the fetus. At a frequency of 39.3%--i.e. every 5th delivery--, umbilical cord complications became a menacing factor to the fetus. The clinical symptoms of fetal(More)