Rolf Kellner

Learn More
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown aetiology. Recent studies have shown that genetic factors and both cellular and humoral immunological abnormalities are important in the pathogenesis of PSC. The most prominent autoantibodies in PSC are anti-neutrophil cytoplasmic antibodies (ANCA). The autoepitopes of(More)
BACKGROUND/AIM Anti-neutrophil cytoplasmic antibodies (ANCA) are a group of autoantibodies first associated with Wegener's granulomatosis and microscopic polyangiitis. The significance of ANCA in autoimmune hepatitis remains uncertain; the nature of the antigen or antigens has not been defined yet. The purpose of this study was to identify the target(More)
417 prematures were treated according to standard therapeutic principles during a period of 2 1/4 years (1. 1. 1969–30. 4. 1971). For 1 year and 10 months (16. 6. 1969–30. 4. 1971) 155 prematures out of the total of 417 received additional treatment with Xantinol nicotinate (Complamin®, Xavin®, Sadamin®). In 27 prematures changes of acid-base values were(More)
The occurrence of anti-neutrophil cytoplasmic antibodies (ANCA) has been described in sera of patients with autoimmune hepatitis (AIH). The significance of this finding remains uncertain and the nature of the target antigen(s) has not yet been defined. We studied 32 sera from patients with AIH type-I and prepared extracts of human neutrophils to identify(More)
Case report on course and radiological symptomatology of malignant thymoma. The unusual course of the young patient and the extensive haematogenic and lymphogenic metastases are stressed. The current opinion on a low tendency of malignant thymoma to metastasize is discussed. Therapeutic regimen and radiological criteria of thymoma are described.
Some authors have recommended peritoneal dialysis to improve the therapy of the respiratory distress syndrome (RDS) of newborns. In 1968 we published a report estimated on a newborn suffering from RDS. As a pH of 6.73, was 2 hrs after birth, we administered standard therapy and peritoneal dialysis. The baby has survived and his development has been(More)
77 mature and 142 premature newborns with respiratory and metabolic acidosis were treated by infusion of buffer solutions. Sodium bicarbonate (2% sodium bicarbonate, 10% sorbitol) and tris-buffer (0.3 Mol THAM per liter, 5% sorbitol, titrated with acetic acid to pH 8.2) were utilised. The mortality was 76.5% in the group with a birth weight of 1250 g and(More)
Bericht über einen 103/12 Jahre alten Knaben, welcher klinisch zahlreiche Stigmata aufwies, die eine Zuordnung zum Ullrich-Turner-Syndrom rechtfertigen, und bei welchem cytogenetisch ein OX/XY/XXY-Mosaik nachweisbar war. Formal wäre der cytogenetische Befund durch non-disjunction in der zweiten und Verlust eines Y-Chromosomes durch anaphase lag in der(More)
Because of examining of possibility of blind infusion of different buffer solutions 14 rabbits got load tests by intravenous infusions of 12 mval/kg sodium bicarbonate, 9 mval/kg THAM resp. 16,7 mval/kg THAM acetic acid. Contrary to the expection, the acid base state proved only an insignificant shifting to alkaline values during and after the drip(More)