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BACKGROUND Dobutamine stress MR (DSMR) is highly accurate for the detection of inducible wall motion abnormalities (IWMAs). Adenosine has a more favorable safety profile and is well established for the assessment of myocardial perfusion. We evaluated the diagnostic value of IWMAs during dobutamine and adenosine stress MR and adenosine MR perfusion compared(More)
AIMS To determine the safety of high-dose dobutamine-atropine stress cardiovascular magnetic resonance (stress-CMR), which recently emerged as a highly accurate modality for diagnosis of inducible myocardial ischaemia. METHOD AND RESULTS From 1997 to 2002, 1000 consecutive stress-CMR examinations were performed. Images were acquired at rest and during a(More)
BACKGROUND T1 mapping is a robust and highly reproducible application to quantify myocardial relaxation of longitudinal magnetisation. Available T1 mapping methods are presently site and vendor specific, with variable accuracy and precision of T1 values between the systems and sequences. We assessed the transferability of a T1 mapping method and determined(More)
PURPOSE To prospectively determine the diagnostic performance of myocardial perfusion magnetic resonance (MR) imaging at 3 T for helping depict clinically relevant coronary artery stenosis (> or =50% diameter) in patients with suspected or known coronary artery disease (CAD), with coronary angiography as the reference standard. MATERIALS AND METHODS The(More)
PURPOSE To prospectively determine feasibility and diagnostic performance (with angiography as reference standard) of k-space and time (k-t) broad-use linear acquisition speed-up technique (k-t BLAST) cine imaging during dobutamine stress for identification of inducible cardiac wall motion abnormalities. MATERIALS AND METHODS The study was conducted(More)
BACKGROUND The purpose of this study was to determine the influence of left ventricular (LV) hypertrophy and geometry on the diagnostic accuracy of wall motion and additional perfusion imaging during high-dose dobutamine/atropine stress magnetic resonance for the detection of coronary artery disease. METHODS AND RESULTS Combined dobutamine stress magnetic(More)
Different pathophysiologic pathways in the development of left ventricular (LV) hypertrophy can be reflected in phenotypical differences. A total of 119 subjects (39 with hypertension [HTN]; 43 with nonobstructive hypertrophic cardiomyopathy [HC], and 37 control subjects) underwent a standardized cardiac magnetic resonance imaging protocol for assessment of(More)
Changes in the process of cross-linking of collagen molecules are associated with defects in the biomechanical stability of the extracellular matrix. Fibrosis of skin is characterized by an increase in pyridinolines, which are hydroxylysine aldehyde derived cross-links usually absent in healthy skin. In this study, we analyzed cross-links in(More)
PURPOSE To prospectively evaluate breath-hold capability and patterns, coronary artery rest periods, and beta-blocker use in coronary magnetic resonance (MR) imaging. MATERIALS AND METHODS Ethics committee approval and informed consent were obtained. In 210 consecutive patients (mean age, 61.8 years +/- 10.3 [standard deviation]; 146 men, 64 women),(More)
OBJECTIVES The aim of the study was to evaluate the feasibility and diagnostic performance of the combination of adenosine stress perfusion and late gadolinium enhancement (LGE) in patients after coronary artery bypass graft surgery (CABG). BACKGROUND Cardiac magnetic resonance (CMR) imaging allows the detection of significant coronary artery disease by(More)