Rolf Günther

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Selection of molecules with desired properties from random pools of biopolymers has become a powerful tool in biotechnology. On designing an evolution experiment, a certain knowledge of the concomitant fitness landscape is clearly helpful to set up the optimal experimental conditions. The correlation function is a useful means of characterizing a given(More)
Zellspezifität und delivery von siRNA sind noch immer bestehende Herausforderungen für deren therapeutische Anwendung. Die neue Technologie einer zielzellspezifischen siRNA erlaubt es, siRNA gezielt zum Abtöten von z. B. Tumorzellen zu verwenden. Cell specificity and delivery of siRNA are still major challenges for therapeutic applications of siRNA. The new(More)
  • Rolf Günther
  • Naunyn-Schmiedebergs Archiv für Pharmakologie und…
  • 2004
The influence of various chelating agents on the distribution and excretion of radioiron, carrier-free or diluted with stable carrier, was studied in rats. Simultaneous administration of chelating agents lowers the retention of radioactive iron in all tissues whereas after delayed treatment a small fraction of storage iron can be removed from liver and(More)
Despite the individually different molecular alterations in tumors, the malignancy associated biological traits are strikingly similar. Results of a previous study using renal cell carcinoma (RCC) as a model pointed towards cancer-related features, which could be visualized as three groups by microarray based gene expression analysis. In this study, we used(More)
Cryptands are possibly useful synthetical models for passive ion carriers in biomembranes. Five mainly Na+ and K+ complex forming cryptands were studied in cardiac Purkinje fibres by means of standard microelectrode techniques. Even at high concentrations the cryptands 22, 221 and 222 showed no effect. Possibly they are not lipophilic enough to accumulate(More)
Mittels cDNA-Microarrays konnten konstant differenziell exprimierte entzündungsassoziierte Gene in der abriebinduzierten und infektiösen periprothetischen Membran nachgewiesen werden. Ziel der vorliegenden Arbeit ist die Validierung der Microarraydaten, um signifikante Unterschiede im Genexpressionsprofil auf RNA- und Proteinebene darzustellen. Gewebeproben(More)