Roland Wörz

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METHOD The analgesic and muscle-relaxing properties of flupirtine maleate, chlormezanone and placebo were compared in a total of 184 patients. Of these patients, 164 met the criteria of the treatment plan (intention to treat), and the data of 140 patients were finally evaluated in accordance with the test protocol. A positive response was defined as a(More)
Two postmarketing studies (PMS) involving 603 patients with neuropathic pain treated with controlled-release oxycodone were performed. Pain intensity and impairment of performance were evaluated using a numeric rating scale (NRS) ranging from 0 to 10 (0 = no pain/impairment, 10 = most severe pain/impairment) measured at the start of the study, and at one(More)
BACKGROUND A guideline for the treatment and diagnostic procedures in fibromyalgia syndrome (FMS) was developed in cooperation with 10 German medical and psychological associations and 2 patient self-help groups. METHODS A systematic literature search including all controlled studies of evaluated multicomponent therapy was performed in the Cochrane(More)
STUDY DESIGN In a multicentric double-blind trial, flupirtine was compared with tramadol in the treatment of cancer pain. METHODS Over a period of four weeks, 4 (-6) capsules containing either 100 mg flupirtine (n = 35) or 50 mg tramadol (n = 36) were taken daily in accordance with a fixed time schedule. Severity of pain was scored on a weekly basis using(More)
BACKGROUND An interdisciplinary guideline for the treatment of fibromyalgia syndrome (FMS) and chronic widespread pain (CWP) was developed in cooperation with ten German medical and psychological associations and two patients' self-help organizations. METHODS Using the Cochrane Collaboration Reviews (1993-12/2006), Medline (1980-2006), PsychInfo(More)
  • R Wörz
  • 1991
With respect to its molecular structure, mechanisms of action and the profile of action and side effects, Flupirtine is an innovative drug. It can be clearly distinguished from acetylsalicylic acid or NSAIDs on the one hand, and opioids on the other. Clinical observations and animal experiments have provided evidence for a muscle-relaxing effect. On the(More)
AIMS Comparison of bisoprolol, a beta-1 selective beta blocker with no intrinsic sympathomimetic activity (ISA) and metoprolol, which numerous studies have shown to be an effective migraine prophylactic. STUDY DESIGN Multicentric, cross-over study. PATIENTS 125 patients suffering at least from 3 attacks of classic or common migraine a month for at least(More)
Six cases out of 38 women patients with persistent headache and abuse of analgesics are described in more detail. From the observations, inferences are drawn for a more specific and critical prescription of analgesics. The continuous taking of commercially available mixed preparations implicates among other risks the danger of the development or(More)
For the treatment of back pain, behavioral modification, pharmacotherapy, non-pharmacological conservative treatment and surgical procedures are available. Systemic and metabolic disorders require specific treatment. Medication that may be considered includes non-opioid analgesics with or without an antiphlogistic action, opioid analgesics, muscle relaxants(More)