Roland Wörz

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STUDY DESIGN In a multicentric double-blind trial, flupirtine was compared with tramadol in the treatment of cancer pain. METHODS Over a period of four weeks, 4 (-6) capsules containing either 100 mg flupirtine (n = 35) or 50 mg tramadol (n = 36) were taken daily in accordance with a fixed time schedule. Severity of pain was scored on a weekly basis using(More)
Eine interdisziplinäre Leitlinie zur Therapie des Fibromyalgiesyndroms (FMS) wurde in Kooperation von 10 medizinischen bzw. psychologischen Fachgesellschaften und 2 Patientenselbsthilfeorganisationen erstellt. Eine Literatursuche über alle kontrollierten Studien zur Therapie des FMS mit psychologischen bzw. psychotherapeutischen Verfahren wurde unter(More)
Im Editorial „Ethik für Anfänger“ regt der Herausgeber zur Diskussion der sog. „Ethik-Charta“ an und wirft die Frage einer Überarbeitung auf [1]. Diese Position möchte ich unterstützen: Das Papier führt eine Vielzahl von Mängeln in Diagnose, Therapie und Prophylaxe, in Ausund Weiterbildung auf dem Gebiet des Schmerzes auf. Das ist inhaltlich richtig, doch(More)
AIMS Comparison of bisoprolol, a beta-1 selective beta blocker with no intrinsic sympathomimetic activity (ISA) and metoprolol, which numerous studies have shown to be an effective migraine prophylactic. STUDY DESIGN Multicentric, cross-over study. PATIENTS 125 patients suffering at least from 3 attacks of classic or common migraine a month for at least(More)
Psychotropic substances combined with simple analgesics are a common pharmacologic denominator in the dependency complex. More than 95 percent of patients studied took preparations containing barbiturates; the remaining few subjects used analgesics combined with caffeine. Dependence on compound analgesic preparations usually develops in patients with(More)
Two postmarketing studies (PMS) involving 603 patients with neuropathic pain treated with controlled-release oxycodone were performed. Pain intensity and impairment of performance were evaluated using a numeric rating scale (NRS) ranging from 0 to 10 (0 = no pain/impairment, 10 = most severe pain/impairment) measured at the start of the study, and at one(More)
METHOD The analgesic and muscle-relaxing properties of flupirtine maleate, chlormezanone and placebo were compared in a total of 184 patients. Of these patients, 164 met the criteria of the treatment plan (intention to treat), and the data of 140 patients were finally evaluated in accordance with the test protocol. A positive response was defined as a(More)
With respect to its molecular structure, mechanisms of action and the profile of action and side effects, Flupirtine is an innovative drug. It can be clearly distinguished from acetylsalicylic acid or NSAIDs on the one hand, and opioids on the other. Clinical observations and animal experiments have provided evidence for a muscle-relaxing effect. On the(More)