Roland P. Johnson

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Human immunodeficiency virus 1 (HIV-1) infection is associated with a vigorous cellular immune response that allows detection of cytotoxic T lymphocyte (CTL) activity using freshly isolated peripheral blood mononuclear cells (PBMC). Although restricting class I antigens and epitopes recognized by HIV-1-specific CTL have been defined, the effector cells(More)
Although the immunologic basis of protective immunity in human immunodeficiency virus type 1 (HIV-1) infection has not yet been defined, virus-specific cytotoxic T lymphocytes (CTL) are likely to be an important host defense and may be a critical feature of an effective vaccine. These observations, along with the inclusion of the HIV-1 envelope in the(More)
Numerous virus-specific, class I-restricted cytotoxic T lymphocyte (CTL) epitopes have been identified, yet little information is available regarding the specificity of the CTL response in persons of the same human histocompatibility leukocyte antigen (HLA) type. In this study, the human immunodeficiency virus (HIV) 1 envelope-specific CTL response was(More)
The Silicon Tracker/Converter of the Gamma-ray Large Area Space Telescope (GLAST) will have an active area of 80 m, representing one of the largest planned applications of the silicon-strip detector technology. The large number of channels (1.3 million) to read out, together with the requirement that the tracker provide the trigger to the data acquisition,(More)
A IDS is the end result of a prolonged dynamic war of attrition between virus and host, marked by prodigious rates of viral replication opposed by host immune responses and remarkable rates of T cell regeneration (1, 2). Understanding the ultimate failure of the host immune responses to control HIV replication remains one of the central challenges of HIV(More)
—This paper discusses the dynamic error characteristics of touch trigger probes used with coordinate measuring machines. During the investigation, a number of important parameters have been identified, including measurement speed, probe longitude, approach distance, probe latitude, stylus length/stylus tip diameter, probe orientation, operating mode(More)
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