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Activation of the mitogen-activated protein kinase (MAPK) cascade after Toll-like receptor stimulation enables innate immune cells to rapidly activate cytokine gene expression. A balanced response to signals of infectious danger requires that cellular activation is transient. Here, we identify the MAPK phosphatase dual specificity phosphatase 1 (DUSP1) as(More)
Novel vaccination strategies against Mycobacterium tuberculosis (MTB) are urgently needed. The use of recombinant MTB antigens as subunit vaccines is a promising approach, but requires adjuvants that activate antigen-presenting cells (APCs) for elicitation of protective immunity. The mycobacterial cord factor Trehalose-6,6-dimycolate (TDM) and its synthetic(More)
  • Sarah Schwitalla, Alexander A. Fingerle, Patrizia Cammareri, Tim Nebelsiek, Serkan I. Göktuna, Paul K. Ziegler +17 others
  • 2013
Cell-type plasticity within a tumor has recently been suggested to cause a bidirectional conversion between tumor-initiating stem cells and nonstem cells triggered by an inflammatory stroma. NF-κB represents a key transcription factor within the inflammatory tumor microenvironment. However, NF-κB's function in tumor-initiating cells has not been examined(More)
IL-10 regulates inflammation by reducing cytokine and chemokine production from activated macrophages. We performed microarray experiments to identify possible effector molecules of IL-10 and to investigate the global effect of IL-10 on the transcriptional response induced in LPS-activated macrophages. To exclude background effects of endogenous IL-10,(More)
Project ARS (artificial recognition system) researches the future possibilities for building automation using bionic approaches. It focuses on the combination of bottom-up data processing systems with decision making inspired by modern psychoanalysis. We define a model based on a symbol processing unit and a decision unit implementing Sigmund Freud's(More)
For a successful yet controlled immune response, cells need to specifically destabilize inflammatory mRNAs but prevent premature removal of those still used. The regulatory circuits controlling quality and timing in the global inflammatory mRNA decay are not understood. Here, we show that the mRNA-destabilizing function of the AU-rich element-binding(More)
In today's technical world (e.g., in the automotive industry), more and more purely mechanical components get replaced by electro-mechanical ones. Thus the size and complexity of embedded systems steadily increases. To cope with this development, comfortable software engineering tools are being developed that allow a more functionality-oriented development(More)
  • Else Marie Agger, Ida Rosenkrands, Jon Hansen, Karima Brahimi, Brian S. Vandahl, Claus Aagaard +7 others
  • 2008
BACKGROUND It is now emerging that for vaccines against a range of diseases including influenza, malaria and HIV, the induction of a humoral response is insufficient and a substantial complementary cell-mediated immune response is necessary for adequate protection. Furthermore, for some diseases such as tuberculosis, a cellular response seems to be the sole(More)
The genome of Epstein-Barr virus (EBV) encodes 86 proteins, but only a limited set is expressed in EBV-growth transformed B cells, termed lymphoblastoid cell lines (LCLs). These cells proliferate via the concerted action of EBV nuclear antigens (EBNAs) and latent membrane proteins (LMPs), some of which are rate limiting to establish a stable homeostasis of(More)