Roland Krüger

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Wnt signaling plays an important role in both oncogenesis and development. Activation of the Wnt pathway results in stabilization of the transcriptional coactivator beta-catenin. Recent studies have demonstrated that axin, which coordinates beta-catenin degradation, is itself degraded. Although the key molecules required for transducing a Wnt signal have(More)
Integration of experimental studies with mathematical modeling allows insight into systems properties, prediction of perturbation effects and generation of hypotheses for further research. We present a comprehensive mathematical description of the cellular response of yeast to hyperosmotic shock. The model integrates a biochemical reaction network(More)
The mobility of the nodes in a Mobile Ad-Hoc Network (MANET) is a crucial factor in the performance studies of communication protocols for these kind of networks. For this reason, researchers usually use a randomized node movement model, such as the Random Way-Point Model [6], in the process of designing or analyzing the behavior of their protocols. Since(More)
We present a framework for model reduction of signal transduction networks. The methods are explained by considering a recent model for Wnt/beta-catenin signalling which plays an important regulatory role in cell development and oncogenesis. The procedure results in a reduction of system variables and parameters while maintaining the ability of the model to(More)
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