Roland Kohan

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We report significant hypotension and prerenal failure in an extremely preterm infant following two doses of oral sildenafil that warranted discontinuation of the drug and treatment with inotropes. Blood pressure and urine output normalized after 24 h of withdrawal of the oral drug. Sildenafil should be used cautiously in extremely preterm infants early in(More)
On January 1984 a protocol for newly diagnosed children with acute lymphoblastic leukemia started in a multiinstitutional setting in Argentina, Costa Rica and Cuba. The protocol was based on the BFM 76/79 study. It consisted in 8 drug 8 weeks induction-consolidation regimen with a delayed intensification regimen followed by maintenance with(More)
PURPOSE To investigate alpha-interferon (IFN) therapy for children with chronic idiopathic thrombocytopenic purpura (ITP). PATIENTS AND METHODS Patients with refractory ITP lasting more than 12 months from diagnosis were included if they had platelet counts <50 x 10(9)/L and had received no treatment during the past month. Patients received IFN (3 x 10(6)(More)
Three hundred and seventy-one children below 16 years, with newly diagnosed acute myeloid leukaemia, were included in six consecutive GATLA/GLATHEM protocols, from November 1967 to December 1987. The study was divided in three periods: 1967 to 1975, 1976 to 1982, and 1983 to 1987. Three induction schedules were used during the first two periods, and(More)
Clinical features and neuroimaging are the modalities frequently used in diagnosing and assessing severity of hydrocephalus in babies. The neonatal electroencephalogramme (EEG) has been well studied and its usefulness in neonatal seizures, neonatal meningitis and prognosis of neurodevelopmental outcomes is well established [1–3]. Previous studies have shown(More)
We would like to commend the authors on excellent research and a well-written article touching on the apparent gap between the increasing effectiveness of antenatal screening in detecting birth defects and the parental satisfaction of the associated health care. We would like to contribute our own regional data and our views as to why this gap may exist. We(More)
A 45-year-old man with primary amyloidosis was initially seen with nephrotic syndrome. Factor X was found to be 5% and antithrombin III (AT III) 45% of normal plasma values. During an 11-month period, despite severe factor X deficiency, the patient did not have any bleeding complications. He developed progressive renal failure and AT III levels increased to(More)
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