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We have investigated the antidepressant efficacy and safety of Hypericum perforatum (St. John's wort) extract WS5572 in a double-blind, placebo-controlled multicenter clinical trial. 72 patients (WS 5572: 37, placebo: 35) with a diagnosis of mild to moderate major depressive disorder (according to DSM-IV criteria) were randomized in 42 days of treatment(More)
BACKGROUND Electroconvulsive therapy (ECT) has gone through fundamental changes since its introduction in 1938 and has developed from a frightening and distrusted procedure into an effective and safe treatment for people with severe psychiatric disorders. This study suggests that ECT has an effect on the response times of simple and complex tasks. METHODS(More)
BACKGROUND Shortened telomere length has been observed in a variety of diseases. Our objective was to analyze mean telomere length of patients with major depressive disorder. A key question was whether telomere length varies in different groups of depressive patients. METHODS We obtained blood samples from patients with major depressive disorder (n = 54)(More)
Depressions increase reaction times and antidepressant treatment decreases them. Is it possible to get information, how these two conditions affect the stimulus-response pathway? Therefore, auditory and visual, left-hand and right-hand, simple and choice reaction times were measured in 38 patients with depression and 30 healthy control subjects. From these(More)
To improve the prediction of suicidal risk one has to understand the suicidal thoughts in individuals. We formalized these ideas and integrated them into an understanding system. In such a system the ideas concerning suicide cooperate in such a way so that the suicidal attempt appears to be the optimal solution for this patient. We discuss the question(More)
In the modern classification systems ICD-10 and DSM-III-R, the term seasonality has been given a separate significance in the diagnostic categorization of affective disorders. Its definition is oriented not merely to the increased seasonal prevalence in the autumn and winter months, but also to symptoms that do not occur in nonseasonal attacks. To date,(More)
A patient suffering from panic attacks without any other clinical signs of epilepsy showed epileptic-form activity in sleep-deprivation EEG. After therapy with carbamazepine, the intensity and number of the panic attacks dropped significantly, whereas therapy with a tricyclic antidepressant had had no effect. Thus, even isolated panic attacks may have an(More)