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OBJECTIVE Sepsis is associated with an increase in reactive oxygen species and low endogenous antioxidative capacity. We postulated that high-dose supplementation of sodium-selenite would improve the outcome of patients with severe sepsis and septic shock. DESIGN Prospective randomized, placebo-controlled, multiple-center trial. SETTING Eleven intensive(More)
BACKGROUND Mechanoreceptors contain compliant elements, termed "gating springs," that transfer macroscopic stimuli impinging on the cells into microscopic stimuli that open the mechanosensitive channels. Evidence for gating springs comes from mechanical experiments; they have not been identified molecularly or ultrastructurally. RESULTS We show that the(More)
BACKGROUND Accelerated bone loss is a well-recognized complication after cardiac transplantation (HTx) due to immunosuppressive therapy. The purpose of this prospective, longitudinal, randomized, placebo-controlled, double-blind study was to investigate the effect of calcitriol (1,25-dihydroxyvitamin D3) in the prevention of bone loss and fracture rate(More)
BACKGROUND/METHODS In Germany, iodine deficiency is common. In a representative group of 2,500 Germans (age >13 years), using a specially designed food questionnaire, the iodine intake was calculated. In addition, iodine and creatinine concentrations in spot urine samples were determined in three groups with a possibly increased risk of iodine deficiency(More)
Der Jodmangel und die damit assoziierten Erkrankungen einschließlich der Jodmangelstruma ist weltweit mit einer Inzidenz von etwa 11% der Gesamtbevölkerung immer noch endemisch. In Deutschland leiden etwa die Hälfte aller 12–14jährigen Schulkinder, etwa ein Drittel aller Frauen und ein Viertel aller Männer an einer Jodmangelstruma [30]. Der(More)
Thyroid volume, urinary iodine excretion as well as personal nutritional knowledge and individual iodine prophylaxis were determined during a health education program on iodine deficiency and prophylaxis in 1992. Participants were 472 male and 568 female (mean age 27.7 years) students and employees of five universities in the southern part of Germany. The(More)
OBJECTIVE To determine the effect of selenium replacement on morbidity and mortality in patients with systemic inflammatory response syndrome (SIRS). DESIGN Controlled, randomized prospective open-label pilot study comparing patients with and without selenium replacement. SETTING Intensive care unit of a university hospital for internal medicine. (More)
Klinisch relevante Schilddrüsenkarzinome sind in 5–6% der operierten Knotenstrumen zu finden. Multinodöse Strumen weisen zudem häufig autonome Areale auf. Daher bedarf es effektiver rationaler differentialdiagnostischer Methoden und Entscheidungsalgorithmen, um unter der großen Zahl der Schilddrüsenknoten diejenigen Knoten mit einem erhöhten Karzinomrisiko(More)
Goitre growth was investigated in rats receiving a low iodine diet (less than 0.1 microgram iodine/g) and either 1 g/l KClO4 or 1 g/l propylthiouracil (PTU), or a combination of KClO4 or PTU with 50.82 nmol/1 T3 in tap water for 3 weeks. To investigate goitre involution, rats with iodine-deficient goitres were treated for 3 weeks either with T3 (0.5(More)