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Insights into the role of ribonuclease 4 polymorphisms in amyotrophic lateral sclerosis
Mutations in certain genes of the Ribonuclease (RNASE) superfamily can cause amyotrophic lateral sclerosis (ALS) through altered RNA processing mechanisms. About 30 of these missense mutations inExpand
Transition path times reveal memory effects and anomalous diffusion in the dynamics of protein folding.
Recent single-molecule experiments probed transition paths of biomolecular folding and, in particular, measured the time biomolecules spend while crossing their free energy barriers. A surprisingExpand
Design of a Toolbox of RNA Thermometers.
Biomolecular temperature sensors can be used for efficient control of large-volume bioreactors, for spatiotemporal imaging and control of gene expression, and to engineer robustness to temperature inExpand
Theoretical and computational validation of the Kuhn barrier friction mechanism in unfolded proteins
A long time ago, Kuhn predicted that long polymers should approach a limit where their global motion is controlled by solvent friction alone, with ruggedness of their energy landscapes having noExpand
Transition Path Times in Non-Markovian Activated Rate Processes.
Transition paths are brief excursions taken by molecules when they cross barriers separating stable molecular conformations. When observed in single-molecule experiments, they offer insights into theExpand
Generalized Langevin Equation as a Model for Barrier Crossing Dynamics in Biomolecular Folding.
Conformational memory in single-molecule dynamics has attracted recent attention and, in particular, has been invoked as a possible explanation of some of the intriguing properties of transitionExpand
Design of a Toolbox of RNA Thermometers
TLDR
We designed a library of RNA thermometers, finding a multiplicity of responses to temperature, ranging from 3.5-fold to over 10-fold in the temperature range 29°C – 37°C. Expand
Kinetics of Loop Closure in Disordered Proteins: Theory vs Simulations vs Experiments.
We study intrachain dynamics of intrinsically disordered proteins, as manifested by the timescales of loop formation, using atomistic simulations, experiment-parametrized coarse-grained models, andExpand
Transition path dynamics of a nanoparticle in a bistable optical trap
Many processes in chemistry, physics, and biology involve rare events in which the system escapes from a metastable state by surmounting an activation barrier. Examples range from chemical reactions,Expand
Transition Path Dynamics of a Dielectric Particle in a Bistable Optical Trap.
Many processes in chemistry, physics, and biology involve rare events in which the system escapes from a metastable state by surmounting an activation barrier. Examples range from chemical reactions,Expand
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