Rohini Patil

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Uterine strips were collected from cows during the follicular and the luteal phases as well as from cows with ovarian cysts. The strips were mounted in organ baths and the motility was recorded by a polygraph. After the spontaneous motility of the strips had reached a steady state the test substances PGF2 alpha and oxytocin were added to the bath at three(More)
The antiprogestin ZK 98.299 (onapristone) was injected subcutaneously (25 mg/day) for 4 consecutive days during early pregnancy to 8 bonnet monkeys. Retrospective analysis of the data showed that the treatment was initiated between 20 to 30 days after the mid-cycle peak in estradiol levels. In 7 animals, vaginal bleeding was induced within 3.6 +/- 2.7 days(More)
The antiprogestin ZK 98.734 (11 beta-(4-dimethylaminophenyl-17 beta-hydroxy-17 alpha-(3-hydroxy-prop-1(Z)-enyl-4,9(10)-estradien-3-one) was administered i.m. (5 mg/day) for three consecutive days to two groups of common marmosets. In one group (nonpregnant, n = 6), it was injected during the luteal phase, and to the second group (pregnant, n = 7), it was(More)
The effects of a progesterone antagonist, lilopristone (ZK 98.734), on induction of menstruation, inhibition of implantation or pregnancy, and termination of early and mid-pregnancy were studied in bonnet monkeys. In the regularly menstruating animals, administration of lilopristone (25 mg/day, s.c.) during the mid-luteal phase (Days 20-22 of the menstrual(More)
The effects of a progesterone antagonist ZK 98.734 (lilopristone) on implantation, early pregnancy, and midpregnancy were studied in the common marmoset, Callithrix jacchus jacchus. Treatment (5 mg/da intramuscularly for 3 consecutive days) on day (n = 8) after the midcycle peak in estradiol levels in mated animals induced a premature drop in plasma(More)
Blood is most essential constituent in human body. Blood centers collect, process and transport blood to hospitals and other health care centers. Sometimes blood is collected directly from blood donors rather than taking it from blood bank. Nowadays donor safety is major issue as blood is collected from different donors. Small amount of donors face(More)
Intramuscular administration of metachlopromide (2.5, 10, and 25 mg) induced increase in serum prolactin levels. Following 10 and 25 mg dose levels, prolactin levels were elevated at least for 8 hr. Single administration of metachlopromide failed to affect the nocturnal rise in circulating levels of testosterone. Daily treatment of metachlopromide (10 mg)(More)
The effects of a progesterone antagonist ZK 98.734 on release of bioactive luteinizing hormone (LH) and testosterone were studied in adult male common marmosets by using the following experimental protocols: (1) the blocking of the nocturnal rise in testosterone levels by ZK 98.734, (2) the pharmacodynamic effects of ZK 98.734 on testosterone and LH levels,(More)