Rohini Khurana

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Advances in cancer management have resulted in a significant increase in median survival of number of diseases. Consequently we are seeing more patients living long enough to develop symptomatic brain metastases. The management of such patients will be discussed here. The most important definitive investigation is contrast enhanced MRI scan of brain.(More)
Survivin is an upregulated inhibitor of apoptosis protein in esophageal cancer (EC), and a promoter region polymorphism (−31G>C) in the survivin gene has been reported as a modulator of gene expression. We aim to explore the role of survivin −31G>C polymorphism in susceptibility and survival of EC patients in northern Indian population. A case–control study(More)
Early diagnosis and better prognosis of esophageal squamous cell carcinoma (ESCC) is still a challenge. Besides environmental risk factors, nutritional deficiencies have an established role in pathogenesis of ESCC. Folate deficiency and functional polymorphisms in folate metabolizing genes such as methylene tetrahydrofolate reductase (MTHFR) 677C>T may have(More)
Uterine papillary serous carcinoma (UPSC) is a biologically aggressive carcinoma that causes a disproportionate number of endometrial cancer deaths because of its dismal clinical outcome. Although the precursor lesion of UPSC has been suggested both morphologically and molecularly, diagnosis continues to represent a challenge to surgical pathologists,(More)
BACKGROUND AND PURPOSE Following our phase II experience, a randomised trial was undertaken to evaluate the efficacy of adding chemotherapy to radiotherapy in patients with unresectable squamous cell cancer of the esophagus. PATIENTS AND METHODS Patients randomised to the RT group received 50 Gy/25 fx/5 weeks of teletherapy followed 1-2 weeks later with(More)
Benzydamine is recommended for prophylaxis of oral mucositis (OM) in head and neck cancer (HNC) patients for radiation doses (<50 Gy). This study evaluates role of benzydamine for higher radiation doses (>50 Gy) with or without chemotherapy. One hundred twenty patients of HNC with planned radiation doses of ≥60 Gy were randomized to group A (control(More)
INTRODUCTION Cisplatin also known as Cis-Diammine-Dichloroplatinum (CDDP) is a chemotherapeutic alkylating nephrotoxic agent. Thus, it is necessary to know if renal function is normal before starting chemotherapy. Glomerular Filtration Rate (GFR) can be assessed directly by using a radiopharmaceutical (dGFR). Estimated GFR (eGFR) method use, Serum(More)
P3 A NEW VERTEBRAL IMPLANT ALLOWING FOR PERCUTANEOUS VERTEBRAL ANATOMICAL RESTORATION DURING VERTEBRAL STABILISATION. PRELIMINARY CLINICAL EXPERIENCE ON 25 PATIENTS AFTER TRAUMATIC BURST FRACTURE AFTER 6 MONTHS FOLLOW UP. X Barreau, C Renaud, E Durandeau, S Luc, S Hansen, JM Vital, V Dousset Service de Neuroradiologie Interventionnelle et Diagnostique,(More)