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The study of regulatory non-coding RNAs has deepened our understanding of cancer on the molecular and clinical front. MicroRNAs, which encompass over 1000 short, endogenous nucleic acids, include important candidates that drive carcino-genesis. In this discussion, we review the literature on miR-135b, purporting its role as an oncogene in multiple cancers,(More)
We have developed a general strategy for creating littermates bearing either a tissue-specific point mutation or deletion in any target gene, and used the method to dissect the roles of Brg, the ATPase subunit of the chromatin-remodeling Brg-associated factor (BAF) complex, in early thymocyte development. We found that a point mutation that inactivates the(More)
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