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The SSN package for R provides a set of functions for modeling stream network data. The package can import geographic information systems data or simulate new data as a 'SpatialStreamNetwork', a new object class that builds on the spatial sp classes. Functions are provided that fit spatial linear models (SLMs) for the 'SpatialStreamNetwork' object. The(More)
OBJECTIVES Application of image-guided surgery to otology has been limited by the need for submillimeter accuracy via a fiducial system that is easily usable (noninvasive and nonobstructive). METHODS A dental bite-block was fitted with a rigid frame with 7 fiducial markers surrounding each external ear. The temporal bones of 3 cadaveric skulls were(More)
Olfactory receptors (ORs) form a large family of G protein-coupled receptor proteins (GPCRs) responsible for sensing the ambient chemical environment. The molecular recognition strategies used by ORs to detect and distinguish odorant molecules are unclear. Here, we investigated the variable of odorant carbon chain conformation for an established odorant-OR(More)
AIMS In symptomatic patients with suspected coronary artery disease (CAD), computed tomographic angiography (CTA) improves patient selection for invasive coronary angiography (ICA) compared with functional testing. The impact of measuring fractional flow reserve by CTA (FFRCT) is unknown. METHODS AND RESULTS At 11 sites, 584 patients with new onset chest(More)
We present a novel estimator for map construction in the presence of segregation distortion which is highly computationally efficient. For multi-parental designs this estimator outperforms methods that do not account for segregation distortion, at no extra computational cost. Inclusion of genetic markers exhibiting segregation distortion in a linkage map(More)
INTRODUCTION Subaxial spine injuries during infancy are uncommon. CASE REPORT We present the case of an infant referred to our brachial plexus clinic with proximal weakness of both arms noted immediately following a complicated breech delivery. Nerve conduction studies were consistent with bilateral proximal upper plexus injury; however, radiological(More)
Glucocorticoid remediable aldosteronism (GRA) is rare familial form of primary aldosteronism characterized by a normalization of hypertension with the administration of glucocorticoids. We present a case of GRA and thoracoabdominal aneurysm complicated by multiple aortic dissections requiring complex surgical and endovascular repairs. Registry studies have(More)
Emergency responders increasingly use social media as a means to monitor public information, gather information that could be used in response efforts, and communicate important information during emergency events. However, the adoption of social media into emergency management processes poses socio-technical challenges such as issues of credibility and(More)
Whether officials can be trusted to protect national security information has become a matter of great public controversy, reigniting a long-standing debate about the scope and nature of official secrecy. The declassification of millions of electronic records has made it possible to analyze these issues with greater rigor and precision. Using(More)