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Biomimetic total syntheses of flinderoles B and C.
A simple and efficient biomimetic synthesis of pyrrolo[1,2-a]indoles using a highly stereo- and regioselective [3 + 2] reaction cascade was developed and then further applied in the first totalExpand
Total Synthesis and Biological Evaluation of Natural and Designed Tubulysins.
The highly potent cytotoxic compounds discovered in this study are highly desirable as payloads for antibody-drug conjugates and other drug delivery systems for personalized targeted cancer chemotherapies. Expand
Biomimetic total syntheses of borreverine and flinderole alkaloids.
A biomimetic approach featuring a scalable and catalytic formal [3 + 2] cycloaddition and Diels-Alder reaction is outlined in detail and a detailed mechanism has been proposed for the dimerization of tertiary alcohol. Expand
Improved Total Synthesis of Tubulysins and Design, Synthesis, and Biological Evaluation of New Tubulysins with Highly Potent Cytotoxicities against Cancer Cells as Potential Payloads for
The extremely potent cytotoxic compounds discovered in these investigations are highly desirable as potential payloads for antibody-drug conjugates and other drug delivery systems for personalized targeted cancer chemotherapies. Expand
Conformational Study and Vibrational Spectroscopic (FT-IR and FT-Raman) Analysis of an Alkaloid-Borreverine Derivative.
A detailed conformational analysis of a borreverine derivative was conducted utilizing density functional theory employing the B3LYP/6-31G(d,p) method to find possible conformers. Expand
Protecting group free enantiospecific total syntheses of structurally diverse natural products of the tetrahydrocannabinoid family.
A simple, highly diastereoselective, Lewis acid catalyzed Friedel-Crafts coupling of a cyclic allylic alcohol with resorcinol derivatives has been developed and achieved with high atom economy, in a protecting group free manner and in less than 6 steps, the longest linear sequence. Expand
Remarkable switch of regioselectivity in Diels-Alder reaction: divergent total synthesis of borreverine, caulindoles, and flinderoles.
Switchable reaction patterns of dimerization of indole substituted butadienes via a Lewis acid and thermal activation are reported, and a complete switch of regioselectivity was observed under thermal conditions. Expand
Structural and spectroscopic analysis of indole alkaloids: Molecular docking and DFT approach
Abstract In the present study, a combined theoretical and experimental approach is used to study the structural properties as well as the activity of isoborreverine. Additionally, the results areExpand
Streamlined Total Synthesis of Trioxacarcins and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues Thereof. Discovery of Simpler Designed and Potent Trioxacarcin
A streamlined total synthesis of the naturally occurring antitumor agents trioxacarcins is described, along with its application to the construction of a series of designed analogues of these complex natural products, with potential applications in cancer therapy, including targeted approaches as in antibody-drug conjugates. Expand
Combine experimental and theoretical investigation on an alkaloid–Dimethylisoborreverine
Abstract A combined experimental (FT–IR, 1 H and 13 C NMR) and theoretical approach is used to study the structure and properties of antimalarial drug dimethylisoborreverine (DMIB). ConformationalExpand