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Psammaplysin H, a new antimalarial bromotyrosine alkaloid from a marine sponge of the genus Pseudoceratina.
Antimalarial activity of pyrroloiminoquinones from the Australian marine sponge Zyzzya sp.
A new bispyrroloiminoquinone alkaloid, tsitsikammamine C (1), displayed potent in vitro antimalarial activity with IC(50) values of 13 and 18 nM against chloroquine-sensitive (3D7) and
Antimalarial bromotyrosine derivatives from the Australian marine sponge Hyattella sp.
A drug discovery program aimed at identifying new antimalarial leads from a prefractionated natural product library has resulted in the identification of a new bromotyrosine alkaloid, psammaplysin G
The Resveratrol Tetramer (-)-Hopeaphenol Inhibits Type III Secretion in the Gram-Negative Pathogens Yersinia pseudotuberculosis and Pseudomonas aeruginosa
Society faces huge challenges, as a large number of bacteria have developed resistance towards many or all of the antibiotics currently available. Novel strategies that can help solve this problem
Acaricidal Activity of Eugenol Based Compounds against Scabies Mites
The acaricidal properties demonstrated by eugenol and its analogues show promise as leads for future development of alternative topical acaricides to treat scabies.
Drug-like properties: guiding principles for the design of natural product libraries.
The present approach addresses front-loading of both extracts and subsequent fractions with desired physicochemical properties prior to screening for drug discovery to ensure timely development of natural product leads at a hitherto unachievable rate.
Thiaplakortones A-D: antimalarial thiazine alkaloids from the Australian marine sponge Plakortis lita.
A high-throughput screening campaign using a prefractionated natural product library and an in vitro antimalarial assay identified active fractions derived from the Australian marine sponge Plakortis lita as thiaplakortones A-D, the most active natural product.
The Diversity and Antimicrobial Activity of Preussia sp. Endophytes Isolated from Australian Dry Rainforests
Endophytic Preussia species that were identified through molecular analysis of the internal transcribed spacer region are described, highlighting the antimicrobial potential of Australian Preussia spp.