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In this study 1 we set out to discover what is learned by children exposed to English morphology. To test for knowledge of morphological rules, we use nonsense materials. We know that if the subject can supply the correct plural ending, for instance, to a noun we have made up, he has internalized a working system of the plural allomorphs in English, and is(More)
Glucocorticoids (GCs) act via intracellular mineralocorticoid (MR) and glucocorticoid receptors (GR). However, it has recently been recognized that GC access to receptors is determined by the presence of tissue-specific 11beta-hydroxysteroid dehydrogenases (11beta-HSDs) that catalyze the interconversion of active corticosterone and inert(More)
Glucocorticoids play important roles in development and 'fetal programming'. Fetal exposure to excess glucocorticoids reduces birth weight and causes later hypertension. To investigate these processes further we have determined the detailed category of 11 beta-hydroxysteroid dehydrogenase type2 (11 beta-HSD2, which potently inactivates glucocorticoids) and(More)
Placental 11␤-hydroxysteroid dehydrogenase (11␤-HSD) regulates transplacental passage of maternal glucocorticoids to the fetus and is thus a key determinant of fetal glucocorticoid levels. It has also been proposed that placental 11␤-HSD expression may influence local glu-cocorticoid actions by regulating access of corticosterone to the glu-cocorticoid(More)
WNK1 and WNK4 are unusual serine/threonine kinases with atypical positioning of the catalytic active-site lysine (WNK: With-No-K[lysine]). Mutations in these WNK kinase genes can cause familial hyperkalemic hypertension (FHHt), an autosomal dominant, hypertensive, hyperkalemic disorder, implicating this novel WNK pathway in normal regulation of BP and(More)
Excessive foetal exposure to glucocorticoids retards growth and "programmes" adult hypertension in rats. Placental 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD), which catalyses the conversion of corticosterone and cortisol to inert 11 keto-products, normally protects the foetus from excess maternal glucocorticoids. In both rats and humans there is(More)
Glucocorticoids (GCs) act via intracellular mineralocorticoid (MR) and glucocorticoid receptors (GR). However, it has recently been recognized that GC access to receptors is determined by the presence of tissue-specific 11␤-hydroxysteroid dehydrogenases (11␤-HSDs) that catalyze the interconversion of active corticosterone and inert 11-dehydrocorticosterone.(More)
The Awards for Distinguished Scientific Contributions are presented bv the Association at the annual convention. The awar dees for 1996. along with those for the preceding years since the establishment of the custom are as follows: Award citations, biographies, and selected bibliographies for Goy and Taylor appeared in the April 1997 issue of the American(More)
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