Roger W Brown

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Placental 11␤-hydroxysteroid dehydrogenase (11␤-HSD) regulates transplacental passage of maternal glucocorticoids to the fetus and is thus a key determinant of fetal glucocorticoid levels. It has also been proposed that placental 11␤-HSD expression may influence local glu-cocorticoid actions by regulating access of corticosterone to the glu-cocorticoid(More)
Glucocorticoids (GCs) act via intracellular mineralocorticoid (MR) and glucocorticoid receptors (GR). However, it has recently been recognized that GC access to receptors is determined by the presence of tissue-specific 11␤-hydroxysteroid dehydrogenases (11␤-HSDs) that catalyze the interconversion of active corticosterone and inert 11-dehydrocorticosterone.(More)
WNK1 and WNK4 are unusual serine/threonine kinases with atypical positioning of the catalytic active-site lysine (WNK: With-No-K[lysine]). Mutations in these WNK kinase genes can cause familial hyperkalemic hypertension (FHHt), an autosomal dominant, hypertensive, hyperkalemic disorder, implicating this novel WNK pathway in normal regulation of BP and(More)
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