Roger Stanev

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OBJECTIVE The aim of this paper is to describe a conceptual framework for how to consider health equity in the GRADE (Grading Recommendations Assessment and Development Evidence) guideline development process. STUDY DESIGN AND SETTING Consensus-based guidance developed by the GRADE working group members and other methodologists. RESULTS We developed(More)
OBJECTIVES This paper introduces the rationale and methods for explicitly considering health equity in the GRADE methodology for development of clinical, public health and health system guidelines. STUDY DESIGN AND SETTING guidance for guideline development STUDY DESIGN AND SETTING: We searched for guideline methodology papers, conceptual papers about(More)
This paper analyzes statistical decisions during the interim analyses of clinical trials. After some general remarks about the ethical and scientific demands of clinical trials, I introduce the notion of a hard-case clinical trial, explain the basic idea behind it, and provide a real example involving the interim analyses of zidovudine in asymptomatic(More)
  • Roger Stanev
  • 2016
This article presents a quantitative way of modeling the interim decisions of clinical trials. While statistical approaches tend to focus on the epistemic aspects of statistical monitoring rules, often overlooking ethical considerations, ethical approaches tend to neglect the key epistemic dimension. The proposal is a second-order decision-analytic(More)
OBJECTIVE to provide guidance for guideline developers on how to consider health equity at key stages of the guideline development process. STUDY DESIGN AND SETTING literature review followed by group discussions and consensus building. RESULTS The key stages at which guideline developers could consider equity include setting priorities, guideline group(More)
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