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Previously we have shown that tamoxifen (TAM) induces morphological and biochemical changes typical of apoptosis in oestrogen receptor (ER)-positive MCF-7 or ER-negative MDA-231 human breast cancer cells. In this study the effects of TAM on expression of transforming growth factor beta 1 (TGF-beta 1) were correlated with the effects on cell cycle kinetics(More)
Surface enhanced laser desorption/ionization (SELDI) time-of-flight mass spectrometry has emerged as a successful tool for serum based detection and differentiation of many cancer types, including breast cancers. In this study, we have applied the SELDI technology to evaluate three potential applications that could extend the effectiveness of established(More)
Glutathione (GSH) has been shown to modulate the cytotoxicity of a variety of chemotherapeutic agents. The effect of mitomycin C (MMC) treatment duration and the effect of GSH depletion on in vitro cytotoxicity against the human colon cancer cell line HT-29 was studied under aerobic conditions. Continuous-exposure experiments revealed that the cytotoxicity(More)
higher survival, and live longer. However, this is not always true for all tumor types. Therefore, the accurate identification and quantifica tion of such prognostic factors could help to identify patients requiring more intensive therapy. However, at this time, it is still not possible to predict with any degree of certainty at the start of treatment(More)
J-M AND MILLER WB. (1994). Expression of transforming growth factor fi mRNA isoforms in human breast cancer. Br. between tamoxifen-induced transforming growth factor PI1 expression. cytostasis and apoptosis in human breast cancer cells. Br. Definition of two distinct mechanisms of action of antiestrogens on human breast cancer cell proliferation using(More)
Glutathione (GSH) has been shown to modulate the Cytotoxicity of a variety of chemotherapeutic agents. The effect of mitomycin C (MMC) treatment duration and the effect of GSH depletion on in vitro cytotox-icity against the human colon cancer cell line 111-29 »asstudied under aerobic conditions. Continuous-exposure experiments revealed that the(More)
BACKGROUND Metastatic breast cancer exhibits diverse and rapidly evolving intra- and inter-tumor heterogeneity. Patients with similar clinical presentations often display distinct tumor responses to standard of care (SOC) therapies. Genome landscape studies indicate that EGFR/HER2/RAS "pathway" activation is highly prevalent in malignant breast cancers. The(More)
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