Roger Parsons

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Previous observations demonstrated that the neurofibromatosis type 2 gene (NF2) plays an important role in the pathogenesis of the transitional, fibroblastic and malignant variants of human meningiomas. No specific genes have been associated with the pathogenesis of meningothelial meningiomas and with the progression to anaplastic meningiomas. However,(More)
AIMS/HYPOTHESIS Insulin controls glucose metabolism via multiple signalling pathways, including the phosphatidylinositol 3-kinase (PI3K) pathway in muscle and adipose tissue. The protein/lipid phosphatase Pten (phosphatase and tensin homologue deleted on chromosome 10) attenuates PI3K signalling by dephosphorylating the phosphatidylinositol(More)
— An innovative new freshman engineering initiative called engage has been fully implemented at the University of Tennessee. This is a comprehensive approach to meeting the educational and developmental needs of our freshmen. Extensive data on student performance was collected during the two-year phase in of this new program. Results presented include(More)
Due to increasing demands for improved teamwork skills in engineering students, a design team facilitator training program was created for engineering upperclassmen. This program is an integral part of the new engage freshman curriculum at the University of Tennessee. The present study is an evaluation of the structure and impact of the program using four(More)
The Engage program is a fresh approach to integrating freshman engineering topics and team design that is in its sixth year of implementation at the University of Tennessee. This initiative is a broad approach, addressing academic, personal skill development and socialization needs of first-year students. Team design projects are designed to complement each(More)
A quantitative assessment was made of the myogenic capability in vitro of muscle cells from dystrophic (129 Rej dy/dy) and normal mice from birth to 5 months old. Seeding efficiency was increased in dystrophic cells from neonatal and 1-week-old mice compared to age-matched controls. The extent of myogenesis in cultures from neonatal and 1-week-old(More)
Triceps and gastrocnemius muscles from dystrophic (129 Rej dy/dy) and normal mice were examined by electron microscopy at different stages in development for evidence of regeneration. Mitotic satellite cells were present only in dystrophic muscle. Myoblasts containing myofilaments, and multinucleate myotubes were observed within foci of regeneration.(More)
Triceps and gastrocnemius muscles from dystrophic (129 ReJ dy/dy) and normal mice were examined by electron microscopy at different stages in development (birth to 6 months). A qualitative assessment was made of the incidence and success of regeneration. Mitotic figures were seen in satellite cells in two-week-old dystrophic muscle. Well-differentiated(More)
The regenerative response of normal and dystrophic muscle cultured with fetal spinal cord has been investigated. Nearly all the normal muscle explants regenerated, but the dystrophic muscle gave a much more varied response as only 30% regenerated, and 38% showed total explant degradation with loss of all recognisable muscle elements. Forty-five % of the(More)
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