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Glucocorticoids bind to hippocampal mineralo-(MR) and gluco-(GR) corticoid receptors and, at high concentrations (e.g. as seen following treatment with pharmacological doses of corticosteroids or during stress), may affect hippocampal neuronal function. Such actions could involve brain-derived neurotrophic factor (BDNF), its receptor, trkB, and the(More)
There is evidence to indicate that cytokines of the interleukin series act within the brain to influence physiological responses to pathological states or stressful events. This investigation examined the effects of intracerebroventricular (lateral ventricle) injection of human recombinant interleukin-1 beta (IL-1 beta) on body temperature, hormone(More)
Three experiments were carried out to investigate stress hyperthermia in prepubertal pigs. Experiment 1 examined the effect of frustrative nonreward (psychological stress) on deep body temperature in animals (n = 7) trained to make operant responses for food following a 17.5-h period of deprivation. There was no change in body temperature when the feeders(More)
Restraint using a nose snare activates the hypothalamo-pituitary-adrenocortical axis and induces c-Fos expression in the paraventricular hypothalamus in the pre-pubertal pig; this procedure also induces hyperthermia in pigs. To investigate the neural mechanisms involved in this thermoregulatory response, c-Fos protein was quantified in the forebrains of(More)
In this study, in situ hybridization histochemistry was used to determine the regional and cellular localization of vasopressin-neurophysin II (AVP) mRNA in the sheep brain and pituitary with an 35S-labelled synthetic 45-mer oligonucleotide probe complementary to the bovine AVP gene. The highest densities of labelled cell bodies were found in the(More)
Prepubertal boars (n = 4/treatment) were killed 24 h after a 5 day course of intravenous injections of dexamethasone (Dex, 1 and 5 mg kg(-1)), or saline vehicle. Gene expression was quantified in brain sections following in situ hybridisation histochemistry. The objective was to determine whether chronic glucocorticoid treatment would alter the expression(More)
Operant feeding and drinking were studied in satiated pigs following injection of 0 (saline vehicle control), 25, 50 or 100 micrograms neuropeptide Y into the lateral cerebral ventricles. Neuropeptide Y stimulated feeding in a dose related manner without any apparent aversive effects. No facilitation of drinking was observed.
Febrile and adrenocortical responses to central (lateral ventricle) injections of prostaglandin E2 (PGE2) and E-series prostanoid receptor agonists (EP1, EP2, EP3, subtypes) were investigated in prepubertal pigs. In Experiment 1, administration of PGE2, (1.4, 5.6 nmol) produced dose-related increases in core temperature and plasma cortisol concentrations.(More)