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Assessment of temporal lobe atrophy from magnetic resonance images is a part of clinical guidelines for the diagnosis of prodromal Alzheimer's disease. As hippocampus is known to be among the first areas affected by the disease, fast and robust definition of hippocampus volume would be of great importance in the clinical decision making. We propose a method(More)
BACKGROUND The New National Institute on Aging-Alzheimer's Association diagnostic guidelines for Alzheimer's disease (AD) incorporate biomarkers in the diagnostic criteria and suggest division of biomarkers into two categories: Aβ accumulation and neuronal degeneration or injury. OBJECTIVE It was the aim of this study to compute hippocampus volume from(More)
UNLABELLED The spatial normalization of PET amyloid imaging data is challenging because different white and gray matter patterns of negative (Aβ-) and positive (Aβ+) uptake could lead to systematic bias if a standard method is used. In this study, we propose the use of an adaptive template registration method to overcome this problem. METHODS Data from a(More)
Alzheimer's disease (AD) and frontal lobe dementia (FLD) show characteristic patterns of regional cerebral blood flow (rCBF). However, these patterns may overlap with those observed in the aging brain in elderly normal individuals. The aim of this study was to develop a new method for better classification and recognition of AD and FLD cases as compared(More)
In this paper we propose a new diagnostic feature for Alzheimer's Disease (AD) which is based on assessment of the degree of inter-hemispheric asymmetry using Single Photon Emission Computed Tomography (SPECT). The asymmetry measure used represents differences in 3D perfusion image patterns in the cerebral hemispheres. We start from the simplest descriptors(More)
UNLABELLED Clinical trials of the PET amyloid imaging agent (18)F-flutemetamol have used visual assessment to classify PET scans as negative or positive for brain amyloid. However, quantification provides additional information about regional and global tracer uptake and may have utility for image assessment over time and across different centers. Using(More)
An evaluation of a new similarity criterion for interindividual image registration is presented. The proposed criterion combines intensity and gradient information from the images to achieve a more robust and accurate registration. It builds on a combination of the normalised mutual information (NMI) cost function and a gradient-weighting function,(More)
Seventeen patients with probable Alzheimer's disease (AD), 7 patients with frontal lobe dementia (FLD) and 19 control subjects (NOR) were examined by (99m)Tc-d,l- hexamethylpropylene amine oxime ((99m)Tc-HMPAO) SPECT. Images were standardised in the same 3D space and averaged within each group. After normalisation, the three sets of images were analysed in(More)
Image registration brings images into a form in which each voxel corresponds to a predetermined anatomic entity and is necessary for comparisons of data across scans. Intrasubject registration is a matter of translating and rotating one image volume into correspondence with another. Intersubject registration is more difficult because it requires the removal(More)