Roger L Williams

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Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells

Roger L Williams, Douglas J. Hilton, +7 authors N. M. Gough
Nature
1988

Embryonic stem (ES) cells, the totipotent outgrowths of bias-tocysts1,2, can be cultured and manipulated in vitro and then returned to the embryonic environment where they develop normally and can… (More)

A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

Zachary A Knight, Beatriz González, +11 authors Kevan M. Shokat
Cell
2006

Phosphoinositide 3-kinases (PI3-Ks) are an important emerging class of drug targets, but the unique roles of PI3-K isoforms remain poorly defined. We describe here an approach to pharmacologically… (More)

Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine.

Edward H. Walker, Michael E Pacold, +4 authors Roger L Williams
Molecular cell
2000

The specific phosphoinositide 3-kinase (PI3K) inhibitors wortmannin and LY294002 have been invaluable tools for elucidating the roles of these enzymes in signal transduction pathways. The X-ray… (More)

The emerging shape of the ESCRT machinery

Roger L Williams, Sylvie Urbé
Nature Reviews Molecular Cell Biology
2007

The past two years have seen an explosion in the structural understanding of the endosomal sorting complex required for transport (ESCRT) machinery that facilitates the trafficking of ubiquitylated… (More)

Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4

Takayuki Obita, Suraj Saksena, +4 authors Roger L Williams
Nature
2007

The AAA+ ATPases are essential for various activities such as membrane trafficking, organelle biogenesis, DNA replication, intracellular locomotion, cytoskeletal remodelling, protein folding and… (More)

A role for the ESCRT system in cell division in archaea.

Rachel Y. Samson, Takayuki Obita, Stefan M.V Freund, Roger L Williams, Stephen D Bell
Science
2008

Archaea are prokaryotic organisms that lack endomembrane structures. However, a number of hyperthermophilic members of the Kingdom Crenarchaea, including members of the Sulfolobus genus, encode… (More)

Structural insights into phosphoinositide 3-kinase catalysis and signalling

Edward H. Walker, Olga Perisic, Christian Ried, L. Scott Stephens, Roger L Williams
Nature
1999

Phosphoinositide 3-kinases (PI3Ks) are ubiquitous lipid kinases that function both as signal transducers downstream of cell-surface receptors and in constitutive intracellular membrane and protein… (More)

Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage.

Ivan Angulo, Oscar Vadas, +41 authors Sergey Nejentsev
Science
2013

Genetic mutations cause primary immunodeficiencies (PIDs) that predispose to infections. Here, we describe activated PI3K-δ syndrome (APDS), a PID associated with a dominant gain-of-function mutation… (More)

Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA.

Alfredo Jacobo-Molina, Jianping Ding, +7 authors Patrick Clark
Proceedings of the National Academy of Sciences…
1993

The crystal structure of a ternary complex of human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) heterodimer (p66/p51), a 19-base/18-base double-stranded DNA template-primer, and a… (More)

Structural role of Sfi1p–centrin filaments in budding yeast spindle pole body duplication

Suo Ping Li, Alan M. Sandercock, Paul T. Conduit, Carol V Robinson, Roger L Williams, John V. Kilmartin
The Journal of cell biology
2006

Centrins are calmodulin-like proteins present in centrosomes and yeast spindle pole bodies (SPBs) and have essential functions in their duplication. The Saccharomyces cerevisiae centrin, Cdc31p,… (More)

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