Roger James Watson

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The protein coding region of the herpes simplex virus type-1 glycoprotein D (gD) gene was mapped, and the nucleotide sequence was determined. The predicted amino acid sequence of the gD polypeptide was found to contain a number of features in common with other virus glycoproteins. Insertion of this protein coding region into a bacterial expressor plasmid(More)
Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) cause both persistent and latent infections, including recurrent cutaneous disease, lethal neonatal disease, central nervous system disease and other clinical syndromes. Modified live vaccines or conventionally prepared subunit vaccines have generally been unsuccessful in the treatment of HSV-1 and(More)
Retinoblastoma like protein 2 (RBL2) or p130 is a member of the pocket protein family, which is infrequently mutated in human tumours. Its expression is posttranscriptionally regulated and largely G0 restricted. We have previously shown that E6/E7 oncoproteins encoded by human papillomavirus (HPV) type 16, which is a high-risk type for cervical cancer(More)
— The next generation of high-resolution numerical weather models require fine-scale (1-5 km) measurements of water vapour over large areas (>20,000 km 2). Existing observing techniques such as GPS are not able to meet these requirements. This paper discusses the feasibility of a novel technique for measuring atmospheric refractivity by the reception and(More)
The opportunistic use of terrestrial microwave links for the measurement of rainfall has the potential to provide several improvements over conventional radar techniques. We present a technique that is capable of producing two-dimensional rainfall fields from a number of measurements of integrated specific attenuation. The approach presented here is able to(More)
The binding of (1)-[3H]vesamicol was characterized in several subcellular fractions and brain regions of the rat. Binding to a lysed P2 fraction from the rat cerebral cortex reached equilibrium within 4 min at 37 degrees C and was reversible (dissociation half-time 4.9 min). At least two binding affinities were found in P2 fractions from the cerebral cortex(More)