Roger G Spragg

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a suction pump to draw air past the mouths of the ventrobronchi into the mesobronchus (1). A glass model demonstrated how this geometry gives rise to unidirectional airflow (1). The mechanism of unidirectional flow in alligator lungs is yet to be determined, but our data support Hazelhoff 's model (1), in which key features of the bronchial tree give rise(More)
INTRODUCTION The purpose of this study was to perform a systematic review and meta-analysis of exogenous surfactant administration to assess whether this therapy may be useful in adult patients with acute respiratory distress syndrome. METHODS We performed a computerized literature search from 1966 to December 2005 to identify randomized clinical trials.(More)
CTP:phosphocholine cytidylyltransferase (CT) is the rate-limiting enzyme in the biosynthesis by type II pneumocytes of phosphatidylcholine (PC), the predominant phospholipid in lung surfactant. Augmentation of endogenous CT activity might therefore result in enhanced surfactant PC production. To test this hypothesis, transgenic mice were created in which(More)
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