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- Roger F. Butterworth
- Metabolic Brain Disease
- 2002
Results of neuropathologic, spectroscopic, and neurochemical studies continue to confirm a major role for ammonia in the pathogenesis of the central nervous system complications of both acute and… (More)
- Margeret S. Swain, Roger F. Butterworth, Andres Thomas Blei
- Hepatology
- 1992
The pathogenesis of brain edema in acute liver failure is poorly understood. We have previously shown that rats with ischemic acute liver failure (portacaval anastomosis followed by hepatic artery… (More)
- Vicente Felipo, Roger F. Butterworth
- Progress in Neurobiology
- 2002
Hyperammonemia resulting from inherited urea cycle enzyme deficiencies or liver failure results in severe central nervous system dysfunction including brain edema, convulsions and coma.… (More)
- Claudia Zwingmann, Nicolas Chatauret, Dieter Leibfritz, Roger F. Butterworth
- Hepatology
- 2003
Acute liver failure (ALF) results in alterations of energy metabolites and of glucose-derived amino acid neurotransmitters in brain. However, the dynamics of changes in glucose metabolism remain… (More)
- Jasmohan S Bajaj, J. M. Massó Córdoba, +4 authors Marsha Yvonne Morgan
- Alimentary pharmacology & therapeutics
- 2011
BACKGROUND
The clinical classification of hepatic encephalopathy is largely subjective, which has led to difficulties in designing trials in this field.
AIMS
To review the current classification of… (More)
- Nicolas Chatauret, Claudia Zwingmann, Christopher Rose, Dieter Leibfritz, Roger F. Butterworth
- Gastroenterology
- 2003
BACKGROUND & AIMS
Mild hypothermia has a protective effect on brain edema and encephalopathy in both experimental and human acute liver failure. The goals of the present study were to examine the… (More)
- Roger F. Butterworth, J. F. Giguere, J L Michaud, Joël Lavoie, Gilles Pomier Layrargues
- Neurochemical pathology
- 1987
There is substantial clinical and experimental evidence to suggest that ammonia toxicity is a major factor in the pathogenesis of hepatic encephalopathy associated with subacute and chronic liver… (More)
- Wenlei Jiang, Paul Desjardins, Roger F. Butterworth
- Journal of cerebral blood flow and metabolism…
- 2009
It has been proposed that proinflammatory mechanisms are involved in the pathogenesis of brain edema in acute liver failure (ALF). The aim of this study was to assess the contribution of cerebral… (More)
- Wenlei Jiang, Paul Desjardins, Roger F. Butterworth
- Journal of neurochemistry
- 2009
Encephalopathy and brain edema are serious complications of acute liver failure (ALF). The precise pathophysiologic mechanisms responsible have not been fully elucidated but it has been recently… (More)
- Roger F. Butterworth, M D Norenberg, Vicente Felipo, P Ferenci, Jan Albrecht, Andres Thomas Blei
- Liver international : official journal of the…
- 2009
Objectives of the International Society for Hepatic Encephalopathy and Nitrogen Metabolism Commission were to identify well-characterized animal models of hepatic encephalopathy (HE) and to highlight… (More)