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Measurements of the particle size distribution at the outlets of six coal-fired utility boilers showed a peak at a particle diameter near 0.1 micrometer. This submicrometer mode appears to be a general feature of coal combustion that results from a volatilization-condensation process in the boiler. At the boilers tested, the submicrometer mode contained 0.2(More)
Galantamine is a modest acetylcholinesterase inhibitor (AChEI) that is also an allosteric potentiating ligand (APL) of nicotinic acetylcholine receptors (nAChRs). In this report, these two effects are shown to be dependent upon each other using a realistic computer model of the cholinergic synaptic cleft. The model is based upon realistic estimates of the(More)
We report measurements of very large output intensities corresponding to a gain larger than 10 5 for a single pass free-electron laser operating in the self-amplified spontaneous emission (SASE) mode at 12 mm. We also report the observation and analysis of intensity fluctuations of the SASE radiation intensity in the high-gain regime. The results are(More)
We discuss whether a new paradigm, quantitative systems pharmacology (QSP), based on computational neuroscience modeling combined with proper drug target engagement and pharmacology, human pathology, imaging studies, and calibration and validation using clinical studies in human subjects might improve the success rate of central nervous systems research and(More)
Digital Subtractive Angiography (DSA) has been performed to image human coronary arteries using wiggler radiation from electron storage rings. The significant medical promise of this procedure motivates the development of smaller and less costly x-ray sources. In this work we present an analysis of these effects as possible sources of intense x-rays at the(More)
of Economics, where he conducts teaching and research in the fi eld of corporate strategy, corporate governance and international competition. He has written extensively in the fi eld of business strategy and industrial performance. He has published three books: Industry in the USA (Penguin 1967), From Empire to Europe: the decline and revival of British(More)
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