Roger Brandt

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Purpose. The goal of this study was to find a rational and reliable method of using animal data to predict the clearance of metabolised drugs in humans. Methods. One such approach is to use in vitro liver models (e.g. hepatocytes and microsomes) to determine the relative capacities of the various animal species and humans to metabolise the test compound.(More)
With the use of specific antibodies against a previously purified [Boehmer, F.-D., Lehmann, W., Schmidt, H., Lange, P., & Grosse, R. (1984) Exp. Cell Res. 150, 466-477] and sequenced mammary-derived growth inhibitor (MDGI) [Boehmer, F.-D., Kraft, R., Otto, A., Wernstedt, C., Hellmann, U., Kurtz, A., Mueller, T., Rohde, K., Etzold, G., Lehmann, W., Langen,(More)
The RAST principle has been utilized for the detection and assay of allergens of various origins. RAST-based methods have the advantage of being convenient, accurate and specific by making use of the IgE antibodies, considered as mediators of the atopic allergic reactions, as reagents in vitro. Two improved assay procedures, a direct titration and an(More)
The present study was undertaken to screen immunochemically for MDGI-related proteins in the mammary gland. A new form, MDGI 2, not present in lactation could be detected in the bovine gland during pregnancy. It was further distinguished from MDGI by its lower molecular weight, its association with a complex binding to WGA, and by lacking immunoreactivity(More)
Cat allergen-specific serum IgE antibodies were detected in 27 (71%) of a group of 38 dog dander-sensitive patients. In 4 (44%) of the cases the dual reaction could be explained by the presence of IgE antibodies to cross-reacting serum proteins. In a larger group the binding of dog dander-specific IgE antibodies could be inhibited by cat epithelium(More)
Plasma or serum of various species which do not yield directly measurable amounts of anaphylatoxin (AT) has been investigated with respect to the presence of the anaphylatoxin-forming enzyme (system), anaphylatoxinogen, and the co-factor (PI) which is necessary for the anaphylatoxin-forming enzyme of cobra venom to form anaphylatoxin. The(More)
 Retinoids, a class of polyisoprenoids including retinol and retinoic acid, regulate and control diverse physiological functions via their cell-differentiating and morphogenic potential. In the present study we showed that the extracellular concentration of retinoid-binding proteins such as albumin limits the amount of retinoid entering the human(More)
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