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When the surgeon identifies an adenoma within the gland and selectively excises it, endocrine-active pituitary tumors are usually cured and pituitary function is preserved. Occasionally ectopic adenomas arise primarily in the pituitary stalk or arise superiorly in the midportion of the anterior lobe and extend upward within the stalk. To determine if these… (More)
Purpose – This paper seeks to investigate the influence of the external environment on the choice of strategic management activities, from a chaos and complexity perspective, since a business environment is a complex adaptive system. Design/methodology/approach – The study in this paper was of an exploratory nature, using the qualitative techniques of case… (More)
OBJECT Thrombolytic treatments for ischemic stroke can restore circulation, but reperfusion injury, mediated by oxygen free radicals, can limit their utility. The authors hypothesized that, during reperfusion, nitric oxide (NO) provides cytoprotection against oxygen free radical species. METHODS Levels of NO and oxygen free radicals were determined in… (More)
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Ether phospholipids have demonstrated both in vitro and in vivo activity against a wide variety of tumor cell lines. The known cyclic ether phospholipid, SRI 62-834, was used as the model to prepare eight novel phospholipids containing a cyclic ether. All of the compounds were as effective as ET-18-OCH3 in their ability to activate macrophage-induced… (More)
In the early part of this century, Toronto eye specialist Dr. James M. MacCallum's keen delight in painting and in helping artists expanded the borders of Canadian art. As friend, patron and confidant to the members of the Group of Seven, he encouraged some of the most recognizable and evocative art ever painted in this country.
Few opera buffs stop to consider how the illnesses suffered by opera's great heroes and heroines mirrored the medical treatments and public attitudes of their time. A Toronto physician and his wife, an English professor and literary critic, have written a book exploring how opera presents illnesses such as tuberculosis and syphilis.