• Publications
  • Influence
Featured Article: Pyruvate preserves antiglycation defenses in porcine brain after cardiac arrest
Cardiac arrest (CA) and cardiocerebral resuscitation (CCR)-induced ischemia–reperfusion imposes oxidative and carbonyl stress that injures the brain. The ischemic shift to anaerobic glycolysis,Expand
  • 4
  • 1
Modeling cardiac arrest and resuscitation in the domestic pig.
Cardiac arrest remains a leading cause of death and permanent disability worldwide. Although many victims are initially resuscitated, they often succumb to the extensive ischemia-reperfusion injuryExpand
  • 28
Pyruvate stabilizes electrocardiographic and hemodynamic function in pigs recovering from cardiac arrest
Cardiac electromechanical dysfunction may compromise recovery of patients who are initially resuscitated from cardiac arrest, and effective treatments remain elusive. Pyruvate, a natural intermediaryExpand
  • 3
Vasopressin instead of epinephrine enhances efficacy of CPR without causing tachycardia (1150.5)
Survival from cardiac arrest is highly dependent on the arterial pressure generated by cardiopulmonary resuscitation (CPR). To increase efficacy of precordial compressions, the potent vasoconstrict...
  • 1
Abstract 127: Pyruvate Improves Electrolyte Homeostasis Following Cardiac Arrest
Purpose: Intravenous infusion of sodium pyruvate can protect internal organs from ischemia-reperfusion imposed by cardiac arrest and resuscitation and may improve patient outcome. Cardiac arrest di...
Intravenous Pyruvate to Prevent Renal Injury Following Cardiac Arrest and Resuscitation
Introduction: Cardiac arrest followed by resuscitation and recovery of spontaneous circulation (ROSC) produces systemic ischemia reperfusion (I/R), affecting all internal organs, including theExpand