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Featured Article: Pyruvate preserves antiglycation defenses in porcine brain after cardiac arrest
Cardiac arrest (CA) and cardiocerebral resuscitation (CCR)-induced ischemia–reperfusion imposes oxidative and carbonyl stress that injures the brain. The ischemic shift to anaerobic glycolysis,… Expand
Modeling cardiac arrest and resuscitation in the domestic pig.
- Brandon H. Cherry, A. Nguyen, Roger A Hollrah, A. Olivencia-Yurvati, R. Mallet
- World journal of critical care medicine
- 4 February 2015
Cardiac arrest remains a leading cause of death and permanent disability worldwide. Although many victims are initially resuscitated, they often succumb to the extensive ischemia-reperfusion injury… Expand
Pyruvate stabilizes electrocardiographic and hemodynamic function in pigs recovering from cardiac arrest
- Brandon H. Cherry, A. Nguyen, +4 authors R. Mallet
- Experimental biology and medicine
- 1 December 2015
Cardiac electromechanical dysfunction may compromise recovery of patients who are initially resuscitated from cardiac arrest, and effective treatments remain elusive. Pyruvate, a natural intermediary… Expand
Vasopressin instead of epinephrine enhances efficacy of CPR without causing tachycardia (1150.5)
Survival from cardiac arrest is highly dependent on the arterial pressure generated by cardiopulmonary resuscitation (CPR). To increase efficacy of precordial compressions, the potent vasoconstrict...
Pyruvate’s Neuroprotection in the Brain Following Cardiac Arrest-Resuscitation
Delayed neuronal death in swine following cardiac arrest and resuscitation (877.12)
Abstract 127: Pyruvate Improves Electrolyte Homeostasis Following Cardiac Arrest
Purpose: Intravenous infusion of sodium pyruvate can protect internal organs from ischemia-reperfusion imposed by cardiac arrest and resuscitation and may improve patient outcome. Cardiac arrest di...
Pyruvate Suppresses Hippocampal MMP-2 Activity Following Cardiac Arrest-Resuscitation
Cytoprotective and Anti-Glycation Defenses in Porcine Brain after Cardiac Arrest and Cardiocerebral Resuscitation
Intravenous Pyruvate to Prevent Renal Injury Following Cardiac Arrest and Resuscitation
- Roger A Hollrah
Introduction: Cardiac arrest followed by resuscitation and recovery of spontaneous circulation (ROSC) produces systemic ischemia reperfusion (I/R), affecting all internal organs, including the… Expand