Rodrigo T. Calado

1Veronica Pons
1Joshua A. Regal
1Julia T. Geyer
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  • Rodrigo T. Calado, Joshua A. Regal, David E. Kleiner, David S. Schrump, Nathan R. Peterson, Veronica Pons +3 others
  • 2009
BACKGROUND Telomerase is an enzyme specialized in maintaining telomere lengths in highly proliferative cells. Loss-of-function mutations cause critical telomere shortening and are associated with the bone marrow failure syndromes dyskeratosis congenita and aplastic anemia and with idiopathic pulmonary fibrosis. Here, we sought to determine the spectrum of(More)
  • Jean-Yves Métais, Thomas Winkler, Julia T. Geyer, Rodrigo T. Calado, Peter D. Aplan, Michael A. Eckhaus +1 other
  • 2012
We previously reported the development of a lethal myeloid sarcoma in a non-human primate model utilizing retroviral vectors to genetically modify hematopoietic stem and progenitor cells. This leukemia was characterized by insertion of the vector provirus into the BCL2A1 gene, with resultant BCL2A1 over-expression. There is little information on the role of(More)
  • Fernanda Gutierrez-Rodrigues, Bárbara A. Santana-Lemos, Priscila S. Scheucher, Raquel M. Alves-Paiva, Rodrigo T. Calado
  • 2014
Telomere length measurement is an essential test for the diagnosis of telomeropathies, which are caused by excessive telomere erosion. Commonly used methods are terminal restriction fragment (TRF) analysis by Southern blot, fluorescence in situ hybridization coupled with flow cytometry (flow-FISH), and quantitative PCR (qPCR). Although these methods have(More)
Telomeres are repeated sequences (the hexanucleotide TTAGGG in vertebrates) located at chromosome ends of eukaryotes, protecting DNA from end joining or degradation. Telomeres become shorter with each cell cycle, but telomerase, a ribonucleoprotein complex, alleviates this attrition. The telomerase RNA component (TERC) is an essential element of telomerase,(More)
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