Rodrigo Molina Martins

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The toxic profile of lawsone (2-hydroxy-[1,4]naphthoquinone) and a series of [1,4]naphthoquinone derivatives was evaluated against the brine shrimp Artemia salina and against the mollusk Biomphalaria glabrata, the main transmitting vector of schistosomiasis in Brazil. Of the seventeen compounds tested nine fell below the threshold of 100 microg/mL set for(More)
New nitrogen derivatives from norlapachol, including four new diastereomeric 1,2,3,4-tetrahydro-1-aza-anthraquinones obtained from the Prins cyclization on suitable aminoacetaldehyde dimethylacetal derivatives with formic acid, were found to exhibit molluscicidal activity against Biomphalaria glabrata. These derivatives showed low to medium LC(50) values,(More)
The molluscicidal profile and brine-shrimp bio-activity of the ethanolic extracts of plants from the Bignoniaceae family were determined. The six extracts investigated were of the stems of Melloa quadrivalvis and Tabebuia aurea, and whole plants of Adenocalymma comosum, Arrabidaea parviflora, Cuspidaria argentea and Clytostoma binatum. When tested in the(More)
PURPOSE Solid-lipid microparticles loaded with high amounts of the sunscreen UV filter benzophenone-3 were prepared by spray congealing with the objective of decreasing its skin penetration and evaluate whether the sunscreen's photoprotection were impaired by the microencapsulation process. METHODS The microparticles were produced using the natural lipids(More)
The molluscicidal activities of ten Baylis-Hillman adducts against Biomphalaria glabrata (Say) snails, the intermediate host of schistosomiasis, have been determined. Nine of these compounds showed significant molluscicidal activity against B. glabrata, falling below the threshold of 100 microg ml(-1) set for potential molluscicidal activity by the World(More)
The title compound, C23H32O4, has a 3beta configuration, with the epoxy O atom at 16alpha,17alpha. Rings A and C have slightly distorted chair conformations. Because of the presence of the C5=C6 double bond, ring B assumes an 8beta,9alpha-half-chair conformation slightly distorted towards an 8beta-sofa. Ring D has a conformation close to a 14alpha-envelope.(More)
Abstract The aim of this study was to investigate the influence of ultrasound and high-shear mixing on the properties of microparticles obtained by spray congealing. Dispersions containing 10% carbamazepine and 90% carrier Gelucire® 50/13 (w/w) were prepared using magnetic stirring, high-shear mixing, or ultrasound. Each preparation was made using hot-melt(More)
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