Rodrigo Miró

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Mantle cell lymphomas (MCLs) are characterized by 11q13 chromosomal translocations and cyclin D1 overexpression. The secondary genetic and molecular events involved in the progression of these tumors are not well known. In this study, we have analyzed 45 MCLs (32 typical and 13 blastoid variants) by comparative genomic hybridization (CGH). To identify the(More)
The long-term cytogenetic effect of radio- or chemotherapy or both on male germ cells was evaluated by study of the chromosomal abnormalities in spermatozoa of four men treated for cancer 5-18 years earlier. The cytogenetic analysis of 422 sperm metaphases showed no differences in the aneuploidy rate. The incidence of structural chromosome aberrations was(More)
The assessment by biological dosimetry of the dose received in cases of partial-body exposure to ionizing radiation can be underestimated because irradiated lymphocytes are mixed with non-irradiated ones. To determine if the exposure affects the whole body or only part of it, it may be useful to know the distribution of cells with more than one dicentric(More)
A total of 660 breakpoints were identified in the chromosome aberrations detected in lymphocytes from cancer patients after radiotherapy. The results show that chromosomes 1, 3, and 7 were significantly more affected than other chromosomes by ionizing radiation in vivo. Chromosome arms 1p, 1q, 7q, and 11p were also significantly more affected. Some bands(More)
Cytogenetic studies were performed in lymphocytes from hospital workers exposed to low doses of radiation (1.6-42.71 mSv). When compared with controls, exposed workers showed a significant increase in structural chromosome-type aberrations, acentric fragments being the most frequent alteration. Our results suggest that acentric fragments are good indicators(More)
We analyzed eight samples of xenografted human pancreatic tumors and two metastases developed in mice by comparative genomic hybridization (CGH). The most recurrent changes were: gains on chromosomes 8 (8q24-qter; 7/8 cases), 15 (15q25-q26; 6/8 cases), 16 (16p in 6/8 cases; 16q in 5/8 cases), 20 (20q; 6/8 cases), and 19 (19q; 5/8 cases); and losses on(More)
The efficiency of the micronucleus test to assess radiation-induced chromosomal damage in human spermatozoa has been investigated. Micronuclei were scored in human sperm-hamster egg hybrids at the two-cell stage, after exposure of human spermatozoa to in vitro gamma-rays at doses of 0.00, 0.10, 0.25, 0.50, 1.00, 2.00, and 4.00 Gy. The relationship between(More)
The cytogenetic effects of in vitro irradiation on human spermatozoa have been studied by the interspecific in vitro fertilization system between human sperm and hamster oocytes. Semen samples from three healthy men were irradiated at doses of 0.00, 0.10, 0.25, 0.50, 1.00, 2.00, and 4.00 Gy. A total of 340 chromosome complements derived from non-irradiated(More)
OBJECTIVES To identify those genetic alterations that are associated with bladder cancer invasion and progression. METHODS A total of 30 specimens of transitional cell carcinoma of the bladder were analyzed by comparative genomic hybridization. The results were compared and summarized with previously reported studies. RESULTS The most frequent(More)