Rodrigo Garcia

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Rett Syndrome is a neurodevelopmental disorder that arises from mutations in the X-linked gene methyl-CpG binding protein 2 (MeCP2). MeCP2 has a large number of targets and a wide range of functions, suggesting the hypothesis that functional signaling mechanisms upstream of synaptic and circuit maturation may contribute to our understanding of the disorder(More)
The impact of activity on neuronal circuitry is complex, involving both functional and structural changes whose interaction is largely unknown. We have used optical imaging of mouse visual cortex responses and two-photon imaging of superficial layer spines on layer 5 neurons to monitor network function and synaptic structural dynamics in the mouse visual(More)
One of the most important issues in Information Retrieval is inferring the intents underlying users' queries. Thus, any tool to enrich or to better contextualized queries can proof extremely valuable. Entity extraction, provided it is done fast, can be one of such tools. Such techniques usually rely on a prior training phase involving large datasets. That(More)
Rett syndrome is a severe childhood onset neurodevelopmental disorder caused by mutations in methyl-CpG-binding protein 2 (MECP2), with known disturbances in catecholamine synthesis. Here, we show that treatment with the β2-adrenergic receptor agonist clenbuterol increases survival, rescues abnormalities in respiratory function and social recognition, and(More)
—The identification of relevant objects in an image is highly relevant in the context of image retargeting. Especially faces draw the attention of viewers. But the level of relevance may change between different faces depending on the size, the location, or whether a face is in focus or not. In this paper, we present a novel algorithm which distinguishes(More)
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